Focal cerebral perfusion defects demonstrated by Tc-99m-hexamethylpropyleneamine oxime SPECT in elderly depressed patients

被引：26

作者：

Vasile, RG ^{[1
]}

Schwartz, RB ^{[1
]}

Garada, B ^{[1
]}

Holman, BL ^{[1
]}

Alpert, M ^{[1
]}

Davidson, PB ^{[1
]}

Schildkraut, JJ ^{[1
]}

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02115

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1996年 / 67卷 / 01期

关键词：

single photon emission computed tomography; affective disorder; aging; geriatric psychiatry; frontal lobe;

D O I：

10.1016/0925-4927(96)02689-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

High resolution single photon emission computed tomography (SPECT) was used to evaluate regional cerebral blood flow (rCBF) in 14 acutely depressed elderly patients and 29 normal subjects. SPECT images of the two groups were randomized and blindly read. Foci of decreased radionuclide uptake were assessed by number and location. The total number of rCBF defects per whole brain study was significantly greater in the depressed patients than in the normal subjects. A significantly greater number of rCBF defects was found most strikingly in the lateral frontal and less prominently in the lateral and medial temporal brain regions of the depressed patients.

引用

页码：59 / 70

页数：12

共 45 条

[1]

*AM PSYCH ASS, 1987, DSM3R DIAGN STAT MAN

[2] TEMPORAL-LOBE ASYMMETRY WITH IOFETAMINE (IMP) SPECT IMAGING IN PATIENTS WITH MAJOR DEPRESSION [J].

AMSTERDAM, JD ;

MOZLEY, PD .

JOURNAL OF AFFECTIVE DISORDERS, 1992, 24 (01) :43-53

[3]

[Anonymous], 1976, PHOTOGRAPHIC ATLAS S, DOI DOI 10.1212/WNL.11.10.852

[4]

[Anonymous], 1985, HALSTEAD REITAN NEUR

[5] SINGLE PHOTON-EMISSION TOMOGRAPHY WITH TC-99M-EXAMETAZIME IN MAJOR DEPRESSION AND THE PATTERN OF BRAIN ACTIVITY UNDERLYING THE PSYCHOTIC NEUROTIC CONTINUUM [J].

AUSTIN, MP ;

DOUGALL, N ;

ROSS, M ;

MURRAY, C ;

OCARROLL, RE ;

MOFFOOT, A ;

EBMEIER, KP ;

GOODWIN, GM .

JOURNAL OF AFFECTIVE DISORDERS, 1992, 26 (01) :31-43

[6]

BAXTER LR, 1985, ARCH GEN PSYCHIAT, V42, P441

[7]

BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243

[8] THE ANATOMY OF MELANCHOLIA - FOCAL ABNORMALITIES OF CEREBRAL BLOOD-FLOW IN MAJOR DEPRESSION [J].

BENCH, CJ ;

FRISTON, KJ ;

BROWN, RG ;

SCOTT, LC ;

FRACKOWIAK, RSJ ;

DOLAN, RJ .

PSYCHOLOGICAL MEDICINE, 1992, 22 (03) :607-615

[9]

CHAN KH, 1994, J NUCL MED, V35, P771

[10]

COFFEY CE, 1993, ARCH GEN PSYCHIAT, V50, P7

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