Aging, graying and loss of melanocyte stem cells

被引：36
作者：
Sarin, Kavita Y. [1 ]
Artandi, Steven E. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
来源：
STEM CELL REVIEWS | 2007年 / 3卷 / 03期
关键词：
stem cells; aging; pigmentation; graying; melanocytes; telomeres; Bcl2; vitiligo; light mutation; HAIR FOLLICLE; NEURAL CREST; SELF-RENEWAL; COAT COLOR; MOUSE; SURVIVAL; NICHE; TELOMERES; KIT; MAINTENANCE;
D O I：
10.1007/s12015-007-0028-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hair graying is one of the prototypical signs of human aging. Maintenance of hair pigmentation is dependent on the presence and functionality of melanocytes, neural crest derived cells which synthesize pigment for growing hair. The melanocytes, themselves, are maintained by a small number of stem cells which reside in the bulge region of the hair follicle. The recent characterization of the melanocyte lineage during aging has significantly accelerated our understanding of how age-related changes in the melanocyte stem cell compartment contribute to hair graying. This review will discuss our current understanding of hair graying, drawing on evidence from human and mouse studies, and consider the contribution of melanocyte stem cells to this process. Furthermore, using the melanocyte lineage as an example, it will discuss common theories of tissue and stem cell aging.
引用
收藏
页码：212 / 217
页数：6
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