Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis

被引:22
作者
Lee, Hye-Bin [1 ,2 ]
Do, Moon-Ho [1 ]
Jhun, Hyunjhung [3 ]
Ha, Sang-Keun [1 ]
Song, Hye-Seon [4 ]
Roh, Seong-Woon [4 ]
Chung, Won-Hyong [1 ]
Nam, Young-Do [1 ]
Park, Ho-Young [1 ]
机构
[1] Korea Food Res Inst, Res Div Food Functional, Wonju 55365, South Korea
[2] Jeonbuk Natl Univ, Dept Food Sci & Technol, Wonju 54896, South Korea
[3] Korea Food Res Inst, Tech Assistance Ctr, Jeonju 55365, South Korea
[4] World Inst Kimchi, Microbiol & Functional Res Grp, Gwangju 61755, South Korea
关键词
Bacteroides uniformis; high-fat diet; non-alcoholic fatty liver disease; hepatic steatosis; lipid metabolism; LIVER-DISEASE; CHREBP;
D O I
10.3390/nu13092989
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Dietary habits and gut microbiota play an essential role in non-alcoholic fatty liver disease (NAFLD) and related factors such as insulin resistance and de novo lipogenesis. In this study, we investigated the protective effects of Bacteroides uniformis CBA7346, isolated from the gut of healthy Koreans, on mice with high-fat diet (HFD)-induced NAFLD. Administration of B. uniformis CBA7346 reduced body and liver weight gain, serum alanine aminotransferase and aspartate aminotransferase levels, liver steatosis, and liver triglyceride levels in mice on an HFD; the strain also decreased homeostatic model assessment for insulin resistance values, as well as serum cholesterol, triglyceride, lipopolysaccharide, leptin, and adiponectin levels in mice on an HFD. Moreover, B. uniformis CBA7346 controlled fatty liver disease by attenuating steatosis and inflammation and regulating de novo lipogenesis-related proteins in mice on an HFD. Taken together, these findings suggest that B. uniformis CBA7346 ameliorates HFD-induced NAFLD by reducing insulin resistance and regulating de novo lipogenesis in obese mice.
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页数:13
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