Targeting the checkpoint kinase WEE1 Selective sensitization of cancer cells to DNA-damaging drugs

被引：21

作者：

Indovina, Paola ^{[1
,2
]}

Giordano, Antonio ^{[1
,2
,3
]}

机构：

[1] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy

[2] Temple Univ, Sbarro Inst Canc Res & Mol Med, Ctr Biotechnol, Coll Sci & Technol, Philadelphia, PA 19122 USA

[3] CROM, Avellino, Italy

来源：

CANCER BIOLOGY & THERAPY | 2010年 / 9卷 / 07期

关键词：

WEE1; G(2) checkpoint abrogators; DNA-damaging agents; p53-deficient cancer cells; MK-1775; G(2) CHECKPOINT; MICROSATELLITE INSTABILITY; TUMOR-CELLS; ABROGATION; CHK1; INHIBITOR; THERAPIES; P53;

D O I：

10.4161/cbt.9.7.11276

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：523 / 525

页数：3

共 23 条

[11]

Menoyo A, 2001, CANCER RES, V61, P7727

[12] Chk1 is a wee1 kinase in the G(2) DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation [J].

OConnell, MJ ;

Raleigh, JM ;

Verkade, HM ;

Nurse, P .

EMBO JOURNAL, 1997, 16 (03) :545-554

[13] Cdc25 and Wee1: analogous opposites? [J].

Perry, Jennifer A. ;

Kornbluth, Sally .

CELL DIVISION, 2007, 2 (1)

[14] The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together [J].

Stracker, TH ;

Theunissen, JWF ;

Morales, M ;

Petrini, JHJ .

DNA REPAIR, 2004, 3 (8-9) :845-854

[15]

Suganuma M, 1999, CANCER RES, V59, P5887

[16] DIFFERENT DRUGS ARREST CELLS AT A NUMBER OF DISTINCT STAGES IN G2 [J].

TOBEY, RA .

NATURE, 1975, 254 (5497) :245-247

[17] Targeting checkpoint kinase 1 in cancer therapeutics [J].

Tse, Archie N. ;

Carvajal, Richard ;

Schwartz, Gary K. .

CLINICAL CANCER RESEARCH, 2007, 13 (07) :1955-1960

[18]

Vassileva V, 2002, CANCER RES, V62, P4095

[19] Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis [J].

Wang, YL ;

Decker, SJ ;

Sebolt-Leopold, J .

CANCER BIOLOGY & THERAPY, 2004, 3 (03) :305-313

[20]

Wang YL, 2001, CANCER RES, V61, P8211

← 1 2 3 →