1,2,3-Triazole hybrids as anticancer agents: A review

被引：215

作者：

Alam, Mohammad Mahboob ^{[1
]}

机构：

[1] Albaha Univ, Fac Sci, Dept Chem, Albaha 1988, Saudi Arabia

来源：

ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 01期

关键词：

1; 2; 3-triazole; cancer; mechanism of action; structure-activity relationship; CARBONIC-ANHYDRASE; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; MOLECULES SYNTHESIS; DESIGN STRATEGIES; CANCER CELLS; DERIVATIVES; TRIAZOLE; DISCOVERY; ANALOGS;

D O I：

10.1002/ardp.202100158

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Despite the advancements in the development of anticancer agents, more effective and safer anticancer drugs still need to be developed as the current agents cause unwanted side effects and many patients have become drug resistant. 1,2,3-Triazoles, due to their remarkable biological potential, have received considerable attention in drug discovery for the development of anticancer agents. The present review article presents an overview of the recent advances in 1,2,3-triazole hybrids with anticancer potential over the last 2 years, their chemical structures, structure-activity relationships, and mechanisms of action, as well as insights into the docking studies.

引用

页数：18

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