Molecular techniques and prostate cancer diagnostic

被引：12

作者：

Montironi, R ^{[1
]}

Mazzucchelli, R ^{[1
]}

Scarpelli, M ^{[1
]}

机构：

[1] Polytech Univ Marche Reg, Sch Med, Inst Pathol Anat & Histopathol, Azienda Osped Umberto 1, I-60020 Torrette, Ancona, Italy

来源：

EUROPEAN UROLOGY | 2003年 / 44卷 / 04期

关键词：

fluorescence in situ hybridization; comparative genomic hybridization; reverse transcription; polymerase chain reaction; DNA array; laser capture microscopy; tissue microarray; prostate cancer;

D O I：

10.1016/S0302-2838(03)00309-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in molecular techniques have given the opportunity to assess genomic and proteomic alterations comprehensively and rapidly in routinely acquired tissue samples. In particular, new markers derived from qualitative and quantitative DNA, RNA, and protein analysis have provided additional objective information to supplant and extend the morphologic interpretations and have been increasingly integrated into the final surgical pathology diagnosis. In this review several recently developed molecular techniques are described and illustrated. The focus is on prostate cancer diagnostics, as an example of their application. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：390 / 400

页数：11

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