We describe a case of a 28-year-old man who developed a cervical myelitis while exposed to ixekizumab (IL-17 inhibitor) for psoriatic arthritis. Spinal MRI showed a T2 hyperintense lesion at the C4-C5 level while brain MRI was unspecific. Oligoclonal bands were absent and extensive screening for autoimmunity was negative. Rechallenge with ixekizumab was positive corroborating a relation between drug exposure and the neurological event. To the best of our knowledge, this is the first case of CNS inflammatory adverse event associated with ixekizumab. We also provide a review of case reports of demyelinating disorders associated with the use of biologic drugs for the treatment of psoriasis and psoriatic arthritis.
机构:
Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Mahil, Satveer K.
Andrews, Thomasin C.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, Dept Neurol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Andrews, Thomasin C.
Brierley, Charlotte
论文数: 0引用数: 0
h-index: 0
机构:
Cambridge Univ Hosp NHS Fdn Trust, Dept Neurol, Cambridge, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Brierley, Charlotte
Barker, Jonathan N.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Barker, Jonathan N.
Smith, Catherine H.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Maillart, Elisabeth
Papeix, Caroline
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Papeix, Caroline
Mellerio, Charles
论文数: 0引用数: 0
h-index: 0
机构:
St Anne Hosp, Dept Neuroradiol, Ctr Psychiat & Neurosci, INSERM,U894, Paris, France
XV XX Hosp, Dept Neuroradiol, Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Mellerio, Charles
Bertrand, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Diagnost & Funct Neuroradiol Dept, Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Bertrand, Anne
Lubetzki, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Lubetzki, Catherine
Louapre, Celine
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
机构:
Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Mahil, Satveer K.
Andrews, Thomasin C.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, Dept Neurol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Andrews, Thomasin C.
Brierley, Charlotte
论文数: 0引用数: 0
h-index: 0
机构:
Cambridge Univ Hosp NHS Fdn Trust, Dept Neurol, Cambridge, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Brierley, Charlotte
Barker, Jonathan N.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
Barker, Jonathan N.
Smith, Catherine H.
论文数: 0引用数: 0
h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, London SE1 7EH, England
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Maillart, Elisabeth
Papeix, Caroline
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Papeix, Caroline
Mellerio, Charles
论文数: 0引用数: 0
h-index: 0
机构:
St Anne Hosp, Dept Neuroradiol, Ctr Psychiat & Neurosci, INSERM,U894, Paris, France
XV XX Hosp, Dept Neuroradiol, Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Mellerio, Charles
Bertrand, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Diagnost & Funct Neuroradiol Dept, Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Bertrand, Anne
Lubetzki, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France
Lubetzki, Catherine
Louapre, Celine
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, FranceHop La Pitie Salpetriere, APHP, Dept Neurol, 47-83 Blvd Hop, F-75013 Paris, France