A review of drug-induced liver injury databases

被引：35
|
作者：
Luo, Guangwen [1 ]
Shen, Yiting [1 ]
Yang, Lizhu [1 ]
Lu, Aiping [2 ]
Xiang, Zheng [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China
[2] Hong Kong Baptist Univ, Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
来源：
ARCHIVES OF TOXICOLOGY | 2017年 / 91卷 / 09期
关键词：
Review; Databases; Drug-induced liver injury; Hepatotoxicity; Liver toxicity; SCALE TOXICOGENOMICS DATABASE; INDUCED HEPATOTOXICITY; ACETAMINOPHEN HEPATOTOXICITY; COMBINATION THERAPY; IN-VITRO; TOXICITY; RISK; EXPRESSION; MODEL; RATS;
D O I：
10.1007/s00204-017-2024-8
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.
引用
收藏
页码：3039 / 3049
页数：11
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