From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment

被引：9
作者：
Soto, Celia A. [1 ]
Lo Celso, Cristina [2 ,3 ]
Purton, Louise E. [4 ,5 ]
Frisch, Benjamin J. [1 ,6 ,7 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Pathol, Rochester, NY 14642 USA
[2] Imperial Coll London, Dept Life Sci, London, England
[3] Sir Francis Crick Inst, London, England
[4] St Vincents Inst Med Res, Fitzroy, Vic, Australia
[5] Univ Melbourne, St Vincents Hosp, Dept Med, Melbourne, Vic, Australia
[6] Univ Rochester, Sch Med & Dent, Wilmot Canc Inst, Rochester, NY 14642 USA
[7] Univ Rochester, Sch Med & Dent, Ctr Musculoskeletal Res, Rochester, NY 14642 USA
来源：
JBMR PLUS | 2021年 / 5卷 / 10期
关键词：
AGING; BONE; CANCER; CHEMOTHERAPY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL (HSC) NICHE; INFLAMMATION; LEUKEMIA; MICROENVIRONMENT; ACUTE MYELOID-LEUKEMIA; STEM-CELL NICHE; MESENCHYMAL STROMAL CELLS; NF-KAPPA-B; SELF-RENEWAL; MYELOGENOUS LEUKEMIA; OSTEOBLASTIC CELLS; ENDOTHELIAL NICHES; PROGENITOR CELLS; T-CELLS;
D O I：
10.1002/jbm4.10516
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The bone marrow microenvironment (BMME) regulates hematopoiesis through a complex network of cellular and molecular components. Hematologic malignancies reside within, and extensively interact with, the same BMME. These interactions consequently alter both malignant and benign hematopoiesis in multiple ways, and can encompass initiation of malignancy, support of malignant progression, resistance to chemotherapy, and loss of normal hematopoiesis. Herein, we will review supporting studies for interactions of the BMME with hematologic malignancies and discuss challenges still facing this exciting field of research. (c) 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
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收藏
页数：10
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共 125 条
  • [41] The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1-CD44 axis
    Godavarthy, Parimala Sonika
    Kumar, Rahul
    Herkt, Stefanie C.
    Pereira, Raquel S.
    Hayduk, Nina
    Weissenberger, Eva S.
    Aggoune, Djamel
    Manavski, Yosif
    Lucas, Tina
    Pan, Kuan-Ting
    Voutsinas, Jenna M.
    Wu, Qian
    Mueller, Martin C.
    Saussele, Susanne
    Oellerich, Thomas
    Oehler, Vivian G.
    Lausen, Joern
    Krause, Daniela S.
    [J]. HAEMATOLOGICA, 2020, 105 (01) : 136 - 147
  • [42] Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells
    Goncalves, Kevin A.
    Silberstein, Lev
    Li, Shuping
    Severe, Nicolas
    Hu, Miaofen G.
    Yang, Hailing
    Scadden, David T.
    Hu, Guo-fu
    [J]. CELL, 2016, 166 (04) : 894 - 906
  • [43] The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis
    Green, Alanna C.
    Tjin, Gavin
    Lee, Samuel C.
    Chalk, Alistair M.
    Straszkowski, Lenny
    Kwang, Diannita
    Baker, Emma K.
    Quach, Julie M.
    Kimura, Takaharu
    Wu, Joy Y.
    Purton, Louise E.
    [J]. BLOOD, 2021, 138 (04) : 304 - 317
  • [44] CXCL12 in early mesenchymal progenitors is. required for haematopoietic stem-cell maintenance
    Greenbaum, Adam
    Hsu, Yen-Michael S.
    Day, Ryan B.
    Schuettpelz, Laura G.
    Christopher, Matthew J.
    Borgerding, Joshua N.
    Nagasawa, Takashi
    Link, Daniel C.
    [J]. NATURE, 2013, 495 (7440) : 227 - 230
  • [45] Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection
    Haltalli, Myriam L. R.
    Watcham, Samuel
    Wilson, Nicola K.
    Eilers, Kira
    Lipien, Alexander
    Ang, Heather
    Birch, Flora
    Anton, Sara Gonzalez
    Pirillo, Chiara
    Ruivo, Nicola
    Vainieri, Maria L.
    Pospori, Constandina
    Sinden, Robert E.
    Luis, Tiago C.
    Langhorne, Jean
    Duffy, Ken R.
    Gottgens, Berthold
    Blagborough, Andrew M.
    Lo Celso, Cristina
    [J]. NATURE CELL BIOLOGY, 2020, 22 (12) : 1399 - +
  • [46] Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
    Haltalli, Myriam L. R.
    Lo Celso, Cristina
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [47] Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche
    Hanoun, Maher
    Zhang, Dachuan
    Mizoguchi, Toshihide
    Pinho, Sandra
    Pierce, Halley
    Kunisaki, Yuya
    Lacombe, Julie
    Armstrong, Scott A.
    Duehrsen, Ulrich
    Frenette, Paul S.
    [J]. CELL STEM CELL, 2014, 15 (03) : 365 - 375
  • [48] T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments
    Hawkins, Edwin D.
    Duarte, Delfim
    Akinduro, Olufolake
    Khorshed, Reema A.
    Passaro, Diana
    Nowicka, Malgorzata
    Straszkowski, Lenny
    Scott, Mark K.
    Rothery, Steve
    Ruivo, Nicola
    Foster, Katie
    Waibel, Michaela
    Johnstone, Ricky W.
    Harrison, Simon J.
    Westerman, David A.
    Quach, Hang
    Gribben, John
    Robinson, Mark D.
    Purton, Louise E.
    Bonnet, Dominique
    Lo Celso, Cristina
    [J]. NATURE, 2016, 538 (7626) : 518 - +
  • [49] Chronic variable stress activates hematopoietic stem cells
    Heidt, Timo
    Sager, Hendrik B.
    Courties, Gabriel
    Dutta, Partha
    Iwamoto, Yoshiko
    Zaltsman, Alex
    von zur Muhlen, Constantin
    Bode, Christoph
    Fricchione, Gregory L.
    Denninger, John
    Lin, Charles P.
    Vinegoni, Claudio
    Libby, Peter
    Swirski, Filip K.
    Weissleder, Ralph
    Nahrendorf, Matthias
    [J]. NATURE MEDICINE, 2014, 20 (07) : 754 - 758
  • [50] Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
    Ho, Ya-Hsuan
    del Toro, Raquel
    Rivera-Torres, Jose
    Rak, Justyna
    Korn, Claudia
    Garcia-Garcia, Andres
    Macias, David
    Gonzalez-Gomez, Cristina
    del Monte, Alberto
    Wittner, Monika
    Waller, Amie K.
    Foster, Holly R.
    Lopez-Otin, Carlos
    Johnson, Randall S.
    Nerlov, Claus
    Ghevaert, Cedric
    Vainchenker, William
    Louache, Fawzia
    Andres, Vicente
    Mendez-Ferrer, Simon
    [J]. CELL STEM CELL, 2019, 25 (03) : 407 - +
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