From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment

被引：9
作者：
Soto, Celia A. [1 ]
Lo Celso, Cristina [2 ,3 ]
Purton, Louise E. [4 ,5 ]
Frisch, Benjamin J. [1 ,6 ,7 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Pathol, Rochester, NY 14642 USA
[2] Imperial Coll London, Dept Life Sci, London, England
[3] Sir Francis Crick Inst, London, England
[4] St Vincents Inst Med Res, Fitzroy, Vic, Australia
[5] Univ Melbourne, St Vincents Hosp, Dept Med, Melbourne, Vic, Australia
[6] Univ Rochester, Sch Med & Dent, Wilmot Canc Inst, Rochester, NY 14642 USA
[7] Univ Rochester, Sch Med & Dent, Ctr Musculoskeletal Res, Rochester, NY 14642 USA
来源：
JBMR PLUS | 2021年 / 5卷 / 10期
关键词：
AGING; BONE; CANCER; CHEMOTHERAPY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL (HSC) NICHE; INFLAMMATION; LEUKEMIA; MICROENVIRONMENT; ACUTE MYELOID-LEUKEMIA; STEM-CELL NICHE; MESENCHYMAL STROMAL CELLS; NF-KAPPA-B; SELF-RENEWAL; MYELOGENOUS LEUKEMIA; OSTEOBLASTIC CELLS; ENDOTHELIAL NICHES; PROGENITOR CELLS; T-CELLS;
D O I：
10.1002/jbm4.10516
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The bone marrow microenvironment (BMME) regulates hematopoiesis through a complex network of cellular and molecular components. Hematologic malignancies reside within, and extensively interact with, the same BMME. These interactions consequently alter both malignant and benign hematopoiesis in multiple ways, and can encompass initiation of malignancy, support of malignant progression, resistance to chemotherapy, and loss of normal hematopoiesis. Herein, we will review supporting studies for interactions of the BMME with hematologic malignancies and discuss challenges still facing this exciting field of research. (c) 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
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页数：10
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