Reduction in Serum Aquaporin-4 Antibody Titers During Development of a Tumor-Like Brain Lesion in a Patient With Neuromyelitis Optica: A Serum Antibody-Consuming Effect?

被引：4

作者：

Aboulenein-Djamshidian, Fahmy ^{[1
,3
]}

Hoeftberger, Romana ^{[4
]}

Waters, Patrick ^{[6
]}

Krampla, Wolfgang ^{[2
]}

Lassmann, Hans ^{[5
]}

Budka, Herbert ^{[4
]}

Vincent, Angela ^{[6
]}

Kristoferitsch, Wolfgang

机构：

[1] SMZ Ost Donauspital, Dept Neurol, A-1220 Vienna, Austria

[2] SMZ Ost Donauspital, Dept Radiol, A-1220 Vienna, Austria

[3] Med Univ Vienna, Karl Landsteiner Inst Neuroimmunol & Neurodegene, Vienna, Austria

[4] Med Univ Vienna, Inst Neurol, Vienna, Austria

[5] Med Univ Vienna, Ctr Brain Res, Dept Neuroimmunol, Vienna, Austria

[6] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Neuroimmunol Grp, Oxford OX3 9DU, England

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2015年 / 74卷 / 03期

关键词：

Aquaporin-4; Brain biopsy; Multiple sclerosis; Neuromyelitis optica; Serum level; Tumor-like lesion; MULTIPLE-SCLEROSIS; WHITE-MATTER; PATHOGENESIS; DISTINCTION; EXPRESSION; ABSENCE;

D O I：

10.1097/NEN.0000000000000173

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the CNS with severe involvement of the optic nerve and spinal cord. Highly specific serum IgG autoantibodies (NMO-IgG) that react with aquaporin-4 (AQP4), the most abundant CNS water channel protein, are found in patients with NMO. However, in vivo evidence combining the results of AQP4 antibody serum levels and brain pathology is lacking. We report a patient with NMO whose AQP4 antibody levels decreased simultaneously with clinical deterioration caused by the development of a tumor-like brain lesion. In the seminecrotic biopsied brain lesion, there was activated complement complex, whereas only very scattered immunoreactivity to AQP4 protein was detectable. The decrease in serum AQP4 antibody levels and the loss of AQP4 in the tumor-like lesion could represent a "serum antibody-consuming effect" during lesion formation.

引用

页码：194 / 197

页数：4

共 17 条

[1] Neocortical neurones may be targeted by immune attack in anti-Yo paraneoplastic syndrome [J].

Aboul-Enein, F. ;

Hoeftberger, R. ;

Buxhofer-Ausch, V. ;

Drlicek, M. ;

Lassmann, H. ;

Budka, H. ;

Kristoferitsch, W. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2008, 34 (02) :248-252

[2] Transient axonal injury in the absence of demyelination:: A correlate of clinical disease in acute experimental autoimmune encephalomyelitis [J].

Aboul-Enein, F ;

Weiser, P ;

Höftberger, R ;

Lassmann, H ;

Bradl, M .

ACTA NEUROPATHOLOGICA, 2006, 111 (06) :539-547

[3] Diffuse White Matter Damage Is Absent in Neuromyelitis Optica [J].

Aboul-Enein, F. ;

Krssak, M. ;

Hoeftberger, R. ;

Prayer, D. ;

Kristoferitsch, W. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2010, 31 (01) :76-79

[4] Neuromyelitis Optica in Austria in 2011: To Bridge the Gap between Neuroepidemiological Research and Practice in a Study Population of 8.4 Million People [J].

Aboul-Enein, Fahmy ;

Seifert-Held, Thomas ;

Mader, Simone ;

Kuenz, Bettina ;

Lutterotti, Andreas ;

Rauschka, Helmut ;

Rommer, Paulus ;

Leutmezer, Fritz ;

Vass, Karl ;

Flamm-Horak, Agathe ;

Stepansky, Robert ;

Lang, Wilfried ;

Fertl, Elisabeth ;

Schlager, Thomas ;

Heller, Thomas ;

Eggers, Christian ;

Safoschnik, Georg ;

Fuchs, Siegrid ;

Kraus, Joerg ;

Assar, Hamid ;

Guggenberger, Stefan ;

Reisz, Martin ;

Schnabl, Peter ;

Komposch, Martina ;

Simschitz, Philipp ;

Skrobal, Alena ;

Moser, Alexander ;

Jeschow, Mario ;

Stadlbauer, Dorothea ;

Freimueller, Manfred ;

Guger, Michael ;

Schmidegg, Susanne ;

Franta, Claudia ;

Weiser, Vera ;

Koppi, Stefan ;

Niederkorn-Duft, Margret ;

Raber, Bettina ;

Schmeissner, Iris ;

Jecel, Julia ;

Tinchon, Alexander ;

Storch, Maria K. ;

Reindl, Markus ;

Berger, Thomas ;

Kristoferitsch, Wolfgang .

PLOS ONE, 2013, 8 (11)

[5] Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica [J].

Hinson, S. R. ;

Pittock, S. J. ;

Lucchinetti, C. F. ;

Roemer, S. F. ;

Fryer, J. P. ;

Kryzer, T. J. ;

Lennon, V. A. .

NEUROLOGY, 2007, 69 (24) :2221-2231

[6] Antibody to aquaporin-4 in the long-term course of neuromyelitis optica [J].

Jarius, S. ;

Aboul-Enein, F. ;

Waters, P. ;

Kuenz, B. ;

Hauser, A. ;

Berger, T. ;

Lang, W. ;

Reindl, M. ;

Vincent, A. ;

Kristoferitsch, W. .

BRAIN, 2008, 131 :3072-3080

[7] Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study [J].

Krampla, Wolfgang ;

Aboul-Enein, Fahmy ;

Jecel, Julia ;

Lang, Wilfried ;

Fertl, Elisabeth ;

Hruby, Walter ;

Kristoferitsch, Wolfgang .

EUROPEAN RADIOLOGY, 2009, 19 (10) :2535-2543

[8] A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis [J].

Lennon, VA ;

Wingerchuk, DM ;

Kryzer, TJ ;

Pittock, SJ ;

Lucchinetti, CF ;

Fujihara, K ;

Nakashima, I ;

Weinshenker, BG .

LANCET, 2004, 364 (9451) :2106-2112

[9] A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica [J].

Lucchinetti, CF ;

Mandler, RN ;

McGavern, D ;

Bruck, W ;

Gleich, G ;

Ransohoff, RM ;

Trebst, C ;

Weinshenker, B ;

Wingerchuk, D ;

Parisi, JE ;

Lassmann, H .

BRAIN, 2002, 125 :1450-1461

[10] Patterns of Antibody Binding to Aquaporin-4 Isoforms in Neuromyelitis Optica [J].

Mader, Simone ;

Lutterotti, Andreas ;

Di Pauli, Franziska ;

Kuenz, Bettina ;

Schanda, Kathrin ;

Aboul-Enein, Fahmy ;

Khalil, Michael ;

Storch, Maria K. ;

Jarius, Sven ;

Kristoferitsch, Wolfgang ;

Berger, Thomas ;

Reindl, Markus .

PLOS ONE, 2010, 5 (05)

← 1 2 →