H3PO4 catalyzed one-pot synthesis of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde to novel 1,3-diphenyl-1H-pyrazole-4-carbonitrile

被引：3

作者：

Choudhare, Tukaram S. ^{[1
]}

Wagare, Devendra S. ^{[2
]}

Shirsath, Sagar E. ^{[3
]}

Netankar, Prashant D. ^{[1
]}

机构：

[1] Maulana Azad Coll, Dept Chem, Aurangabad 431004, Maharashtra, India

[2] Sardar Dalipsingh Commerce & Sci Coll, Dept Chem, Vivekanand Arts, Auranagbad 43002, India

[3] Univ New South Wales, Sch Mat Sci & Engn, Sydney, NSW 2052, Australia

来源：

JOURNAL OF CHEMICAL SCIENCES | 2021年 / 133卷 / 03期

关键词：

Pyrazole-4-carbaldehyde; pyrazole-4-carbonitrile; H3PO4; formic acid; OXIDATIVE CONVERSION; ALDEHYDES; NITRILES; AMMONIA; DIAMINOMALEONITRILE; TRANSFORMATION; REACTIVITY; CYANATION;

D O I：

10.1007/s12039-021-01939-w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot condensation of pyrazole-4-aldehydes and hydroxylamine hydrochloride to form the corresponding oxime using formic acid as a medium and further dehydration of oxime using a catalytic amount of orthophosphoric acid to afford novel pyrazole-4-carbonitrile. This protocol serves as an ortho-phosphoric acid-catalyzed one-pot conversion of aldehyde to nitrile. Most remarkable features of this method are metal-free, cost-effective, atom efficiency with excellent yield (98-99%). This process will serve as a robust and scalable tool for the synthesis of valuable and versatile precursor (nitriles). This precursor will pave the way for the synthesis of various medicinally important valuable compounds. Graphic abstract H3PO4 catalysed transformation of aldehydes to nitriles

引用

页数：7

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