Synthesis of (Hetero)Aroyl Fluorides via a Mild Amides C-N Bond Cleavage

被引：14

作者：

Aliyu Idris, Muhammad ^{[1
]}

Song, Kwang Ho ^{[2
]}

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea

[2] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 14期

基金：

新加坡国家研究基金会;

关键词：

amides; N-benzoylsaccharin; fluorides; acyl fluorides; C-N Bond Cleavage; CARBOXYLIC-ACIDS; ACYL FLUORIDES; HYDROGEN-FLUORIDE; KETONE SYNTHESIS; CONVENIENT; ESTERIFICATION; CARBONYLATION; FLUORINATION; ACTIVATION; ACYLATION;

D O I：

10.1002/adsc.202200275

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Amides, such as N-benzoylsaccharin, N,N-diBocbenzamide, and N-phenyl-N-tosylbenzamides reacted with Et3N.3HF to provide the corresponding acyl fluorides in good yields. The reaction was conducted under environmentally friendly conditions using i-PrOAc as the solvent. Moreover, the reaction was performed at room temperature and did not require a transition-metal catalyst or additives. The methodology showed functional group tolerance toward amines, alkoxy, halides, ketones, esters, and aldehydes.

引用

收藏

页码：2449 / 2453

页数：5

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