Chronic cannabidiol exposure promotes functional impairment in sexual behavior and fertility of male mice

被引：45

作者：

Carvalho, Renata K. ^{[1
]}

Souza, Maingredy R. ^{[1
]}

Santos, Monaliza L. ^{[1
]}

Guimaraes, Francisco S. ^{[2
]}

Pobbe, Roger Luis H. ^{[1
]}

Andersen, Monica L. ^{[3
]}

Mazaro-Costa, Renata ^{[1
]}

机构：

[1] Univ Fed Goias, Dept Pharmacol, Lab Physiol & Pharmacol Reprod, Goiania, Go, Brazil

[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP, Brazil

[3] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil

来源：

REPRODUCTIVE TOXICOLOGY | 2018年 / 81卷

关键词：

Cannabinoids; Ejaculation; Acrosome reaction; Progesterone; SEA-URCHIN SPERM; PROGESTERONE-RECEPTOR; COPULATORY-BEHAVIOR; CANNABINOIDS; MARIJUANA; ENDOCANNABINOIDS; TESTOSTERONE; DELTA-9-THC; INHIBITION; MODULATION;

D O I：

10.1016/j.reprotox.2018.06.013

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cannabidiol (CBD) is a potent substance extracted from Cannabis sativa. As it has been suggested that marijuana can affect the reproductive system, we decided to assess the effects of chronic CBD exposure on the male reproductive system in an animal model. 21-day old male Swiss mice received CBD for 34 consecutive days at doses (p.o.) of either 15 or 30 mg/kg, and a control group received sunflower oil. Body weight gain and circulating progesterone concentration did not significantly change in CBD-treated animals. In the sexual behavior analysis, the CBD 15 group presented a delay in performing the first mount and intromission, and a reduced number of mounts and ejaculations. The CBD 30 group showed a 30% reduction in fertility rate and a 23% reduction in the number of litters. Our results indicate that chronic CBD exposure promotes functional impairment of the reproductive system of male Swiss mice.

引用

页码：34 / 40

页数：7

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