Conventional tumor markers are prognostic indicators in patients with head and neck squamous cell carcinoma

被引：48

作者：

Kimura, Y ^{[1
]}

Fujieda, S ^{[1
]}

Takabayashi, T ^{[1
]}

Tanaka, T ^{[1
]}

Sugimoto, C ^{[1
]}

Saito, H ^{[1
]}

机构：

[1] Fukui Med Univ, Dept Otorhinolaryngol, Matsuoka, Fukui 9101193, Japan

来源：

CANCER LETTERS | 2000年 / 155卷 / 02期

关键词：

tumor marker; prognosis; squamous cell carcinoma-related antigen; immunosuppressive acid protein; sialic acid; head and neck cancer;

D O I：

10.1016/S0304-3835(00)00423-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We tested for squamous cell carcinoma-related antigen (SCC), carcinoembryonic antigen (CEA), ferritin, immunosupprrssive acid protein (IAP) and sialic acid in the serum from 247 patients with head and neck squamous cell carcinoma prior to therapy. Significant correlations were found between IAP and tumor size, lymph node metastasis, and clinical stage (P < 0.0001, P < 0.001. and P < 0.0001). Also, sialic acid and SCC were also correlated with tumor size, lymph node metastasis, and clinical stage. Moreover IAP, sialic acid and SCC were strongly associated with survival rate (P < 0.0001, P = 0.0230 and P = 0.0159). A multivariate Cox proportional hazard model demonstrated that bring positive for IAP was an independent predictor for patients with H&NSCC (P = 0.0115). The results indicate that IAP, sialic acid and SCC are useful as prognostic factors. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：163 / 168

页数：6

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