Scyllo-inositol in normal aging human brain:: 1H magnetic resonance spectroscopy study at 4 Tesla

被引：38

作者：

Kaiser, LG

Schuff, N

Cashdollar, N

Weiner, MW

机构：

[1] VA Med Ctr, MR Unit, San Francisco, CA 94121 USA

[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

来源：

NMR IN BIOMEDICINE | 2005年 / 18卷 / 01期

关键词：

Scyllo-inositol; myo-inositol; taurine; 4T; spectroscopy; human brain; white matter; aging;

D O I：

10.1002/nbm.927

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using H-1 magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter re-ion of the corona radiata. Test-retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：51 / 55

页数：5

共 29 条

[1]

Bartha R, 2000, MAGNET RESON MED, V44, P185, DOI 10.1002/1522-2594(200008)44:2<185::AID-MRM4>3.0.CO

[2]

2-V

[3] In vivo proton magnetic resonance spectroscopy of the normal aging human brain [J].