Platelet- and Megakaryocyte-Derived Microparticles

被引：69

作者：

Flaumenhaft, Robert ^{[3
]}

Mairuhu, Albert T. A.

Italiano, Joseph E., Jr. ^{[1
,2
]}

机构：

[1] Childrens Hosp Boston, Dept Surg, Vasc Biol Program, Boston, MA USA

[2] Brigham & Womens Hosp, Div Translat Med, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Ctr Life Sci, Dept Med, Div Hemostasis & Thrombosis, Boston, MA 02215 USA

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2010年 / 36卷 / 08期

关键词：

Microparticle; platelet; megakaryocyte; cytoskeleton; PLASMA-MEMBRANE; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; ACTIVATED PLATELETS; HORIZONTAL TRANSFER; ENDOTHELIAL-CELLS; MICROVESICLES; PROCOAGULANT; PHOSPHATIDYLSERINE; VESICULATION; CYTOSKELETON;

D O I：

10.1055/s-0030-1267042

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.

引用

页码：881 / 887

页数：7

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