Knockdown of the FoxM1 enhances the sensitivity of gastric cancer cells to cisplatin by targeting Mcl-1

被引：14
作者：
Li, Xiaomei [1 ]
Liang, Jun [2 ]
Liu, Ying-Xun [3 ]
Wang, Yuming [4 ]
Yang, Xiao-Hui [1 ]
Bao-Hongluan [1 ]
Zhang, Gui-Ling [1 ]
Du, Juan [1 ]
Wu, Xia-Hong [1 ]
机构：
[1] Taishan Univ, Chengyang Peoples Hosp, Dept Oncol, Affiliated Hosp Med, Qingdao, Peoples R China
[2] Qingdao Univ, Affiliated Hosp, Coll Med, Dept Oncol, Qingdao 266071, Peoples R China
[3] Taishan Univ, Affiliated Hosp Med, Chengyang Peoples Hosp, Dept Resp, Changcheng Rd 600, Qingdao 266109, Peoples R China
[4] Taishan Univ, Affiliated Hosp Med, Chengyang Peoples Hosp, Dept Pathol, Qingdao, Peoples R China
来源：
PHARMAZIE | 2016年 / 71卷 / 06期
关键词：
TRANSCRIPTION FACTOR FOXM1; HEPATOCELLULAR-CARCINOMA; EXPRESSION; OVEREXPRESSION; PROGRESSION; CHEMORESISTANCE; PROLIFERATION; ANGIOGENESIS; INHIBITION; TRANSITION;
D O I：
10.1691/ph.2016.5850
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Resistance to chemotherapy is a main obstacle for effective treatment of gastric cancer, the mechanism of which is still poorly understood. Forkhead box M1 (FoxM1) plays an important role in chemo-resistance of various tumors. This study aimed to explore whether FoxM1 mediated resistance of the gastric cancer cell line SGC7901 to the chemotherapy agent cisplatin (DDP). In the study, we detected FoxM1 and Mcl-1 expression via real time-PCR and western blot and demonstrated that FoxM1 is overexpressed in cisplatin-resistance GC cells and Mcl-1 expression is regulated by FoxM1. We examined SGC7901/DDP cell viability by MTT assay, which revealed that suppression of the FoxM1/Mcl-1 pathway impaired cell viability and thus increased sensitivity to cisplatin in gastric cancer cells. Taken together, the study implied that the FoxM1/Mcl-1 pathway may overcome cispaltin resistance of gastric cancer and provide a new therapeutic target for the treatment of gastric cancer.
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收藏
页码：345 / 348
页数：4
相关论文
共 27 条
[1]   RETRACTED: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors (Retracted article. See vol. 158, pg. 607, 2016) [J].
Ahmad, Aamir ;
Wang, Zhiwei ;
Kong, Dejuan ;
Ali, Shadan ;
Li, Yiwei ;
Banerjee, Sanjeev ;
Ali, Raza ;
Sarkar, Fazlul H. .
BREAST CANCER RESEARCH AND TREATMENT, 2010, 122 (02) :337-346
[2]   Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells [J].
Akagi, Hideko ;
Higuchi, Hajime ;
Sumimoto, Hidetoshi ;
Igarashi, Toru ;
Kabashima, Ayano ;
Mizuguchi, Hiroyuki ;
Izumiya, Motoko ;
Sakai, Gen ;
Adachi, Masayuki ;
Funakoshi, Shinsuke ;
Nakamura, Shoko ;
Hamamoto, Yasuo ;
Kanai, Takanori ;
Takaishi, Hiromasa ;
Kawakami, Yutaka ;
Hibi, Toshifumi .
GASTRIC CANCER, 2013, 16 (01) :100-110
[3]  
[Anonymous], CANCER
[4]   Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer [J].
Bektas, Nuran ;
ten Haaf, Anette ;
Veeck, Juergen ;
Wild, Peter Johannes ;
Luescher-Firzlaff, Juliane ;
Hartmann, Arndt ;
Knuechel, Ruth ;
Dahl, Edgar .
BMC CANCER, 2008, 8 (1)
[5]   FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells [J].
Chiu, Wen-Tai ;
Huang, Yu-Fang ;
Tsai, Huei-Yu ;
Chen, Chien-Chin ;
Chang, Chang-Hwa ;
Huang, Soon-Cen ;
Hsu, Keng-Fu ;
Chou, Cheng-Yang .
ONCOTARGET, 2015, 6 (04) :2349-2365
[6]   FoxM1 is Overexpressed in Helicobacter pylori-Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370 [J].
Feng, Yimin ;
Wang, Lixiang ;
Zeng, Jiping ;
Shen, Li ;
Liang, Xiuming ;
Yu, Han ;
Liu, Shili ;
Liu, Zhifang ;
Sun, Yundong ;
Li, Wenjuan ;
Chen, Chunyan ;
Jia, Jihui .
MOLECULAR CANCER RESEARCH, 2013, 11 (08) :834-844
[7]   Translational research in gastric malignancy [J].
Johnson, Sara M. ;
Evers, B. Mark .
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2008, 17 (02) :323-+
[8]   Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice [J].
Kalin, TV ;
Wang, IC ;
Ackerson, TJ ;
Major, ML ;
Detrisac, CJ ;
Kalinichenko, VV ;
Lyubimov, A ;
Costa, RH .
CANCER RESEARCH, 2006, 66 (03) :1712-1720
[9]   Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor [J].
Kalinichenko, VV ;
Major, ML ;
Wang, XH ;
Petrovic, V ;
Kuechle, J ;
Yoder, HM ;
Dennewitz, MB ;
Shin, B ;
Datta, A ;
Raychaudhuri, P ;
Costa, RH .
GENES & DEVELOPMENT, 2004, 18 (07) :830-850
[10]   miR-449 inhibits cell proliferation and is down-regulated in gastric cancer [J].
Kheir, Tony Bou ;
Futoma-Kazmierczak, Ewa ;
Jacobsen, Anders ;
Krogh, Anders ;
Bardram, Linda ;
Hother, Christoffer ;
Gronbaek, Kirsten ;
Federspiel, Birgitte ;
Lund, Anders H. ;
Friis-Hansen, Lennart .
MOLECULAR CANCER, 2011, 10
123