Treatment of Skin Cancers in Epidermolysis Bullosa

被引：18

作者：

Venugopal, Supriya S. ^{[1
]}

Murrell, Dedee F. ^{[1
]}

机构：

[1] Univ New S Wales, St George Hosp, Dept Dermatol, Sydney, NSW 2217, Australia

来源：

DERMATOLOGIC CLINICS | 2010年 / 28卷 / 02期

关键词：

Epidermolysis bullosa; Biopsy; Diagnosis; SQUAMOUS-CELL CARCINOMA; MARJOLINS-ULCER; GROWTH-FACTOR; SINGLE-AGENT; NODE BIOPSY; HEAD; CETUXIMAB; BURN; EXPRESSION; MANAGEMENT;

D O I：

10.1016/j.det.2010.01.009

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Squamous cell carcinomas (SCCs) are highly aggressive in patients with epidermolysis bullosa (EB). Non ultraviolet-related SCCs are the leading cause of death in patients with recessive dystrophic EB, particularly recessive dystrophic EB-generalized severe subtype (RDEB-GS). The mechanism of SCC development in patients with RDEB continues to be investigated and several theories have been reported in the literature.

引用

页码：283 / +

页数：7

共 36 条

[1] Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma [J].

Arbiser, JL ;

Fan, CY ;

Su, XB ;

van Emburgh, BO ;

Cerimele, F ;

Miller, MS ;

Harvell, J ;

Marinkovich, MP .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (04) :788-790

[2] Basic fibroblast growth factor: A missing link between collagen VII, increased collagenase, and squamous cell carcinoma in recessive dystrophic epidermolysis bullosa [J].

Arbiser, JL ;

Fine, JD ;

Murrell, D ;

Paller, A ;

Connors, S ;

Keough, K ;

Marsh, E ;

Folkman, J .

MOLECULAR MEDICINE, 1998, 4 (03) :191-195

[3] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

[4] PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type, hormone refractory prostate cancer cells [J].

Bouali, Sanae ;

Chretien, Anne-Sophie ;

Ramacci, Carole ;

Rouyer, Marie ;

Becuwe, Philippe ;

Merlin, Jean-Louis .

ONCOLOGY REPORTS, 2009, 21 (03) :731-735

[5] Very acute and aggressive form of Marjolin's ulcer caused by single blunt trauma to the burned area [J].

Copcu, E ;

Sivrioglu, N ;

Baytekin, C ;

Koc, B ;

Er, S .

JOURNAL OF BURN CARE & REHABILITATION, 2005, 26 (05) :459-460

[6]

Dupree MT, 1998, CUTIS, V62, P49

[7] Chemoprevention of squamous cell carcinoma in recessive dystrophic epidermolysis bullosa: Results of a phase 1 trial of systemic isotretinoin [J].

Fine, JD ;

Johnson, LB ;

Weiner, M ;

Stein, A ;

Suchindran, C .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 50 (04) :563-571

[8] Possible role for sentinal mode biopsy in the management of squamous cell carcinomas in inherited epidermolysis bullosa [J].

Fine, JD .

ARCHIVES OF DERMATOLOGY, 2004, 140 (08) :1012-1013

[9]

FINE JD, 1999, EPIDERMOLYSIS BULLOS, V1, P206

[10] Epidermolysis bullosa and the risk of life-threatening cancers: The National EB Registry experience, 1986-2006 [J].

Fine, Jo-David ;

Johnson, Lorraine B. ;

Weiner, Madeline ;

Li, Kuo-Ping ;

Suchindran, Chirayath .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (02) :203-211

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