Metastatic components in colorectal cancer

被引：7
作者：
Javarsiani, Marjan Hajimoradi [1 ]
Javanmard, Shagayegh Haghjooy [2 ]
Colonna, Francesca [3 ]
机构：
[1] Shiraz Univ, Sch Vet Med, Dept Basic Sci, Shiraz, Iran
[2] Isfahan Univ Med Sci, Appl Physiol Res Ctr, Cardiovasc Res Inst, Esfahan, Iran
[3] Cattolica Sacro Cuore Largo Francesco Univ, Dept Gen Pathol, Rome, Italy
来源：
JOURNAL OF RESEARCH IN MEDICAL SCIENCES | 2019年 / 24卷
关键词：
Cancer stem cells; colorectal cancer; metastasis; tumor microenvironment; GROWTH-FACTOR RECEPTOR; STROMAL FIBROBLASTS; TUMOR ANGIOGENESIS; STEM-CELLS; EXPRESSION; HETEROGENEITY; ACTIVATION; MODEL; SMAD4;
D O I：
10.4103/jrms.JRMS_957_18
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs). In this review, we discuss interactions between CSCs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer.
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页数：7
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