Correlation of clinical findings and brain volume data in multiple sclerosis

被引：15

作者：

Fragoso, Yara Dadalti ^{[1
]}

Wille, Paulo Roberto ^{[2
,3
]}

Abreu, Marcelo ^{[4
]}

Brooks, Joseph Bruno B. ^{[1
]}

Dias, Ronaldo Maciel ^{[5
]}

Duarte, Juliana Avila ^{[6
,7
]}

Farage, Luciano ^{[8
]}

Finkelsztejn, Alessandro ^{[6
,7
]}

Frohlich, Alan Christmann ^{[9
,10
]}

Magno Goncalves, Marcus Vinicius ^{[2
,3
]}

Sobreira Guedes, Bruno V. ^{[11
]}

Medeiros, Leonardo ^{[12
]}

Oliveira, Rodrigo Andre ^{[13
]}

Ribas, Flavio Diniz ^{[14
]}

Gomes da Rocha, Fernando Coronetti ^{[12
]}

Santos, Gutemberg Augusto C. ^{[15
]}

Scorcine, Claudio ^{[1
]}

da Silveira, Guilherme Lopes ^{[13
]}

Spedo, Carina Tellaroli ^{[16
]}

Tauil, Carlos Bernardo ^{[8
]}

Varela, Juliana Santos ^{[6
,7
]}

Ferreira Vieira, Vera Lucia ^{[17
]}

机构：

[1] Univ Metropolitana Santos, Dept Neurol, Santos, SP, Brazil

[2] Univ Regiao Joinville, Dept Neurol, Joinville, SC, Brazil

[3] Univ Regiao Joinville, Dept Radiol, Joinville, SC, Brazil

[4] Clinoson Image, Dept Radiol, Porto Alegre, RS, Brazil

[5] Hosp Base Dist Fed, Dept Neurol, Brasilia, DF, Brazil

[6] Hosp Clin Porto Alegre, Dept Neurol, Porto Alegre, RS, Brazil

[7] Hosp Clin Porto Alegre, Dept Radiol, Porto Alegre, RS, Brazil

[8] Univ Brasilia, Fac Hlth Sci, Brasilia, DF, Brazil

[9] Dept Neurol, Passo Fundo, RS, Brazil

[10] Dept Neurosurg Passo Fundo, Passo Fundo, RS, Brazil

[11] Multscan Image, Dept Radiol, Vitoria, ES, Brazil

[12] Univ Estadual Sao Paulo, Dept Neurol, Botucatu, SP, Brazil

[13] Megaimagem, Dept Radiol, Santos, SP, Brazil

[14] Hosp Dona Helena, Dept Neurol, Joinville, SC, Brazil

[15] Univ Estacio Sa, Dept Neurol, Rio De Janeiro, RJ, Brazil

[16] Univ Sao Paulo, Dept Neurosci & Behav Sci, Campus Ribeirao Preto, Ribeirao Preto, SP, Brazil

[17] Univ Fed Espirito Santo, Dept Neurol, Vitoria, ES, Brazil

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2017年 / 44卷

关键词：

Multiple sclerosis; Brain volume; Brain atrophy; Disability; Magnetic resonance image; DISABILITY PROGRESSION; ATROPHY;

D O I：

10.1016/j.jocn.2017.06.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain volume measurements are becoming an important tool for assessing success in controlling multiple sclerosis (MS) activity. MSmetrix (icometrix) is an easy-to-use platform, specific for MS magnetic resonance imaging (MRI) of the brain. It provides data on total brain volume, grey matter volume and lesion load volume. The objective of the present study was to assess whether disability and the number of relapses during the previous year correlated with brain volume measurements from MSmetrix. Data on 185 icometrix reports from patients with MS were used to evaluate the potential correlation between brain volume measurements and clinical parameters. There was a significant correlation between higher disability and decreased brain volume (total and grey matter). Increased lesion load in the brain and higher number of relapses in the previous year were also independently correlated with decreased brain tissue volume and with increased disability. This is the first study with real-world data to show that icometrix is a relevant tool for the study of brain volume loss in MS. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：155 / 157

页数：3

共 10 条

[1] Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability [J].

De Stefano, N ;

Narayanan, S ;

Francis, SJ ;

Smith, S ;

Mortilla, M ;

Tartaglia, MC ;

Bartolozzi, ML ;

Guidi, L ;

Federico, A ;

Arnold, DL .

ARCHIVES OF NEUROLOGY, 2002, 59 (10) :1565-1571

[2] Clinical Relevance of Brain Volume Measures in Multiple Sclerosis [J].

De Stefano, Nicola ;

Airas, Laura ;

Grigoriadis, Nikolaos ;

Mattle, Heinrich P. ;

O'Riordan, Jonathan ;

Oreja-Guevara, Celia ;

Sellebjerg, Finn ;

Stankoff, Bruno ;

Walczak, Agata ;

Wiendl, Heinz ;

Kieseier, Bernd C. .

CNS DRUGS, 2014, 28 (02) :147-156

[3] Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study [J].

Jacobsen, Cecilie ;

Hagemeier, Jesper ;

Myhr, Kjell-Morten ;

Nyland, Harald ;

Lode, Kirsten ;

Bergsland, Niels ;

Ramasamy, Deepa P. ;

Dalaker, Turi O. ;

Larsen, Jan Petter ;

Farbu, Elisabeth ;

Zivadinov, Robert .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2014, 85 (10) :1109-1115

[4] Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images [J].

Jain, Saurabh ;

Sima, Diana M. ;

Ribbens, Annemie ;

Cambron, Melissa ;

Maertens, Anke ;

Van Hecke, Wim ;

De Mey, Johan ;

Barkhof, Frederik ;

Steenwijk, Martijn D. ;

Daams, Marita ;

Maes, Frederik ;

Van Huffel, Sabine ;

Vrenken, Hugo ;

Smeets, Dirk .

NEUROIMAGE-CLINICAL, 2015, 8 :367-375

[5]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

[6] Brain atrophy: an in-vivo measure of disease activity in multiple sclerosis [J].

Radue, Ernst Wilhelm ;

Bendfeldt, Kerstin ;

Mueller-Lenke, Nicole ;

Magon, Stefano ;

Sprenger, Till .

SWISS MEDICAL WEEKLY, 2013, 143

[7] Brain MRI atrophy quantification in MS From methods to clinical application [J].

Rocca, Maria A. ;

Battaglini, Marco ;

Benedict, Ralph H. B. ;

De Stefano, Nicola ;

Geurts, Jeroen J. G. ;

Henry, Roland G. ;

Horsfield, Mark A. ;

Jenkinson, Mark ;

Pagani, Elisabetta ;

Filippi, Massimo .

NEUROLOGY, 2017, 88 (04) :403-413

[8] Reliable measurements of brain atrophy in individual patients with multiple sclerosis [J].

Smeets, Dirk ;

Ribbens, Annemie ;

Sima, Diana M. ;

Cambron, Melissa ;

Horakova, Dana ;

Jain, Saurabh ;

Maertens, Anke ;

Van Vlierberghe, Eline ;

Terzopoulos, Vasilis ;

Van Binst, Anne-Marie ;

Vaneckova, Manuela ;

Krasensky, Jan ;

Uher, Tomas ;

Seidl, Zdenek ;

De Keyser, Jacques ;

Nagels, Guy ;

De Mey, Johan ;

Havrdova, Eva ;

Van Hecke, Wim .

BRAIN AND BEHAVIOR, 2016, 6 (09)

[9] Brain Volume Loss During the First Year of Interferon-Beta Treatment in Multiple Sclerosis: Baseline Inflammation and Regional Brain Volume Dynamics [J].

Vidal-Jordana, Angela ;

Sastre-Garriga, Jaume ;

Perez-Miralles, Francisco ;

Pareto, Deborah ;

Rio, Jordi ;

Auger, Cristina ;

Tintore, Mar ;

Rovira, Alex ;

Montalban, Xavier .

JOURNAL OF NEUROIMAGING, 2016, 26 (05) :532-538

[10] A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients [J].

Zivadinov, Robert ;

Uher, Tomas ;

Hagemeier, Jesper ;

Vaneckova, Manuela ;

Ramasamy, Deepa P. ;

Tyblova, Michaela ;

Bergsland, Niels ;

Seidl, Zdenek ;

Dwyer, Michael G. ;

Krasensky, Jan ;

Havrdova, Eva ;

Horakova, Dana .

MULTIPLE SCLEROSIS JOURNAL, 2016, 22 (13) :1709-1718

← 1 →