Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells

被引：9
作者：
Oda, Toru [1 ,3 ]
Kume, Toshiaki [1 ]
Izumi, Yasuhiko [1 ]
Ishihara, Kumatoshi [3 ]
Sugmimoto, Hachiro [2 ]
Akaike, Akinori [1 ]
机构：
[1] Kyoto Univ, Dept Pharmacol, Sakyo Ku, Kyoto 6068501, Japan
[2] Kyoto Univ, World Leading Drug Discovery Res Ctr, Sakyo Ku, Kyoto 6068501, Japan
[3] Hiroshima Int Univ, Neuropharmacol Lab, Fac Pharmaceut Sci, Hiroshima 7370112, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2011年 / 116卷 / 01期
关键词：
Na+/Ca2+ exchanger (NCX); neurite outgrowth; PC12; NERVE GROWTH-FACTOR; MYOSIN LIGHT-CHAIN; CALCIUM; KINASE; PHOSPHORYLATION; NEURONS; PATHWAY;
D O I：
10.1254/jphs.11011SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To elucidate the role of Na+/Ca2+ exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho ROCK signal transduction pathways in neurite outgrowth.
引用
收藏
页码：128 / 131
页数：4
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