Effects of olfactory bulbectomy on NMDA receptor density in the rat brain:: [3H] MK-801 binding assay

被引：28

作者：

Ho, YJ

Liu, TM

Tai, MY

Wen, ZH

Chow, RSS

Tsai, YF

Wong, CS

机构：

[1] Triserv Gen Hosp, Dept Anesthesiol, Taipei 114, Taiwan

[2] Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei, Taiwan

[3] Natl Def Med Ctr, Taipei 114, Taiwan

[4] Univ Calif Irvine, Sch Biol Sci, Irvine, CA 92717 USA

来源：

BRAIN RESEARCH | 2001年 / 900卷 / 02期

关键词：

olfactory bulbectomy; irritability; NMDA receptor; H-3] MK-801 binding; cerebral cortex; amygdala;

D O I：

10.1016/S0006-8993(01)02297-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats were correlated with discrete regional effects on NMDA receptor function measured using a [H-3] MK-801 binding assay. Irritability scores, measured before and for 2 weeks after OBX, showed a gradual increase in irritability after OBX. A reduction of the NMDA receptor density was observed in the cerebral cortex and amygdala 16 days after OBX, but not in the striatum, olfactory tubercle, entorhinal cortex, and hippocampus. These results demonstrate that OBX causes changes in the NMDA receptor system in certain brain regions and suggest that these changes may be responsible for the behavioral deficits of OBX rats. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：214 / 218

页数：5

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