APOE ε4 and Alzheimer's disease -: Positive association in a Colombian clinical series and review of the Latin-American studies

被引:27
作者
Jacquier, M
Arango, D
Villareal, E
Torres, O
Serrano, ML
Cruts, M
Montañes, P
Cano, C
Rodriguez, MN
Serneels, S
Van Broeckhoven, C
机构
[1] Inst Nacl Salud, Grp Chron Dis, B-2020 Bogota, Colombia
[2] Univ Javeriana, Memory Clin, Bogota, Colombia
[3] Univ Antwerp VIB, Born Bunge Fdn, Dept Biochem, Antwerp, Belgium
关键词
Alzheimer's disease; APOE; dementia; risk factors; ethnic groups; Colombia;
D O I
10.1590/S0004-282X2001000100004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: As the strength of the association between the APOE epsilon4 allele and Alzheimer's disease (AD) varies across ethnic groups, we studied if there was such an association in Colombian patients. Method: We performed apolipoprotein E (APOE) genotyping in a clinical sample of 83 unrelated AD patients, predominantly late-onset (>65 yrs) including familial (n = 30) and sporadic AD cases (n = 53) diagnosed according to NINCDS-ADRDA criteria and assessed by a multi-disciplinary team. Control subjects (n = 44) had no significant cognitive impairment by medical interview and neuro-psychological testing. Results: We found a high association (OR = 5.1 95%Cl 1.9 - 13.6) between APOE epsilon4 and AD, in this series with predominantly late-onset cases with familial aggregation in 24 cases (28.9%). A significant negative association was found between epsilon2 and AD (OR = 0.2 95% CI 0.05 - 0.75). Conclusion: Further population-based surveys in Colombia are warranted to precise a possible dose effect of APOE epsilon4.
引用
收藏
页码:11 / 17
页数:7
相关论文
共 39 条
  • [1] APOLIPOPROTEIN E4 ALLELE FREQUENCY IN SPANISH ALZHEIMER AND CONTROL CASES
    ADROER, R
    SANTACRUZ, P
    BLESA, R
    LOPEZPOUSA, S
    ASCASO, C
    OLIVA, R
    [J]. NEUROSCIENCE LETTERS, 1995, 189 (03) : 182 - 186
  • [2] The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle
    Aguilar, CA
    Talavera, G
    Ordovas, JM
    Barriguete, JA
    Guillén, LE
    Leco, ME
    Pedro-Botet, J
    Gonzalez-Barranco, J
    Gómez-Pérez, FJ
    Rull, JA
    [J]. ATHEROSCLEROSIS, 1999, 142 (02) : 409 - 414
  • [3] Apolipoprotein E4 and Alzheimer's disease: In Sao Paulo - Brazil
    Almeida, OP
    Shimokomaki, CM
    [J]. ARQUIVOS DE NEURO-PSIQUIATRIA, 1997, 55 (01) : 1 - 7
  • [4] Barker W, 1998, JAMA-J AM MED ASSOC, V280, P1661, DOI 10.1001/jama.280.19.1661
  • [5] APOLIPOPROTEIN-E, EPSILON-4 ALLELE AS A MAJOR RISK FACTOR FOR SPORADIC EARLY AND LATE-ONSET FORMS OF ALZHEIMERS-DISEASE - ANALYSIS OF THE 19Q13.2 CHROMOSOMAL REGION
    CHARTIERHARLIN, MC
    PARFITT, M
    LEGRAIN, S
    PEREZTUR, J
    BROUSSEAU, T
    EVANS, A
    BERR, C
    VIDAL, O
    ROQUES, P
    GOURLET, V
    FRUCHART, JC
    DELACOURTE, A
    ROSSOR, M
    AMOUYEL, P
    [J]. HUMAN MOLECULAR GENETICS, 1994, 3 (04) : 569 - 574
  • [6] Combarros O, 1998, ACTA NEUROL SCAND, V97, P68
  • [7] The role of APOE polymorphisms in late-onset dementias
    Corder, EH
    Lannfelt, L
    Bogdanovic, N
    Fratiglioni, L
    Mori, H
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 1998, 54 (09) : 928 - 934
  • [8] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES
    CORDER, EH
    SAUNDERS, AM
    STRITTMATTER, WJ
    SCHMECHEL, DE
    GASKELL, PC
    SMALL, GW
    ROSES, AD
    HAINES, JL
    PERICAKVANCE, MA
    [J]. SCIENCE, 1993, 261 (5123) : 921 - 923
  • [9] CORREA JPJ, IN PRESS HUMAN HERED
  • [10] Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population
    de-Andrade, FM
    Larrandaburu, M
    Callegari-Jacques, SM
    Gastaldo, G
    Hutz, MH
    [J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2000, 33 (05) : 529 - 537