Anti-tumor necrosis factor-α monoclonal antibody therapy for rheumatoid arthritis

被引：66
作者：
Kavanaugh, AF
机构：
[1] Univ Texas, SW Med Sch, Dallas, TX 75235 USA
[2] Vet Adm N Texas Hlth Care Syst, Dallas, TX USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1998年 / 24卷 / 03期
关键词：
D O I：
10.1016/S0889-857X(05)70028-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Because it plays a central role in the immunopathogenesis of rheumatoid arthritis (RA), TNF-alpha is an attractive target for immunomodulatory therapy. In a number of rigorous studies, monoclonal antibodies (mAb) specific for TNF-alpha have proved efficacious in patients with active RA. Data from these studies and issues related to mechanisms of action, potential toxicity, and future directions for this novel therapeutic approach are considered in this review.
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页码：593 / +
页数：23
相关论文
共 70 条
[1]   DOES TUMOR-NECROSIS-FACTOR PROTECT AGAINST LUPUS IN WEST AFRICANS [J].
ADEBAJO, AO .
ARTHRITIS AND RHEUMATISM, 1992, 35 (07) :839-840
[2]   STABILIZATION OF THE BIOACTIVITY OF TUMOR-NECROSIS-FACTOR BY ITS SOLUBLE RECEPTORS [J].
ADERKA, D ;
ENGELMANN, H ;
MAOR, Y ;
BRAKEBUSCH, C ;
WALLACH, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (02) :323-329
[3]   INHIBITION OF THE PRODUCTION AND EFFECTS OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN RHEUMATOID-ARTHRITIS [J].
AREND, WP ;
DAYER, JM .
ARTHRITIS AND RHEUMATISM, 1995, 38 (02) :151-160
[4]   The tumor necrosis factor ligand and receptor families [J].
Bazzoni, F ;
Beutler, B .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1717-1725
[5]   A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells [J].
Black, RA ;
Rauch, CT ;
Kozlosky, CJ ;
Peschon, JJ ;
Slack, JL ;
Wolfson, MF ;
Castner, BJ ;
Stocking, KL ;
Reddy, P ;
Srinivasan, S ;
Nelson, N ;
Boiani, N ;
Schooley, KA ;
Gerhart, M ;
Davis, R ;
Fitzner, JN ;
Johnson, RS ;
Paxton, RJ ;
March, CJ ;
Cerretti, DP .
NATURE, 1997, 385 (6618) :729-733
[6]  
BRENNAN FM, 1989, LANCET, V2, P244
[7]  
CHOY E, 1995, ARTHRITIS RHEUM S, V38, P185
[8]   Rheumatoid arthritis and the risk of malignancy [J].
Cibere, J ;
Sibley, J ;
Haga, M .
ARTHRITIS AND RHEUMATISM, 1997, 40 (09) :1580-1586
[9]   INCREASED LEVELS OF SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTORS IN THE SERA AND SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATIC DISEASES [J].
COPE, AP ;
ADERKA, D ;
DOHERTY, M ;
ENGELMANN, H ;
GIBBONS, D ;
JONES, AC ;
BRENNAN, FM ;
MAINI, RN ;
WALLACH, D ;
FELDMANN, M .
ARTHRITIS AND RHEUMATISM, 1992, 35 (10) :1160-1169
[10]   Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling [J].
Cope, AP ;
Liblau, RS ;
Yang, XD ;
Congia, M ;
Laudanna, C ;
Schreiber, RD ;
Probert, L ;
Kollias, G ;
McDevitt, HO .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (09) :1573-1584
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