A new multifunctional polymer Synthesis and characterization of mPEG-b-PAA-grafted chitosan copolymer

被引：5

作者：

Liu Cheng-bin ^{[1
,2
]}

Wang Xiao-jian ^{[2
]}

Liu Rong-hua ^{[1
,2
]}

Wu Yu-lin ^{[2
]}

Luo Sheng-lian ^{[1
,2
]}

机构：

[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

来源：

JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY | 2010年 / 17卷 / 05期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

chitosan; polyacrylic acid (PAA); polyethylene glycol (PEG); multifunction polymer; synthesis; characterization; AMPHIPHILIC BLOCK-COPOLYMERS; PLASMID DNA; GENE; DELIVERY; MICELLES;

D O I：

10.1007/s11771-010-0580-7

中图分类号：

TF [冶金工业];

学科分类号：

0806 ;

摘要：

A new multifunctional mPEG-b-PAA-grafted chitosan copolymer possessing amino and carboxyl groups, mPEG-b PAA-g CHI (compound 6), was designed for a potential application in gene/drug delivery and synthesized by the methods of reversible addition-fragmentation chain transfer (RAFT) polymerization of acrylic acid (AA) and grafting reaction of a biodegradable chitosan (CHI) derivative Completion of the reactions and characterization of the resulting compounds were demonstrated by H-1 NMR, FTIR and gel permeation chtomatography (GPC) studies The results show that the molar ratio of amino groups to carboxyl groups in the copolymer (compound 6) is 0 41 0 59

引用

页码：936 / 942

页数：7

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