Modular StarPEG-Heparin Gels with Bifunctional Peptide Linkers

被引：48

作者：

Tsurkan, Mikhail V. ^{[1
]}

Chwalek, Karolina ^{[1
]}

Levental, Kandice R. ^{[1
]}

Freudenberg, Uwe ^{[1
]}

Werner, Carsten ^{[1
]}

机构：

[1] CRTD, Max Bergmann Ctr Biomat Dresden, Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2010年 / 31卷 / 17期

关键词：

biodegradable; biomimetic; heparin; peptides; starPEG; GROWTH-FACTOR; BIOACTIVE HYDROGELS; DELIVERY-SYSTEMS; CELL; DIFFERENTIATION; RELEASE; DEGRADATION; SCAFFOLDS; ADHESION; THERAPY;

D O I：

10.1002/marc.201000155

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Cell responsive materials are instrumental to regenerative therapies. Here, we report about a novel biohybrid hydrogel that consists of heparin and peptide-conjugated star-shaped poly(ethylene glycol), crosslinked by peptide units that combine matrix metalloproteinase (MMP) sensitivity and cell adhesive modules. Taking advantage of the high affinity of vascular endothelial growth factor to heparin, we illustrate the applicability of our hydrogels as a novel system that is supportive of cellular remodeling and three-dimensional migration of human endothelial cells.

引用

页码：1529 / 1533

页数：5

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