Solubility and Apparent Specific Volume of Some Pharmaceutical Salts in Propylene Glycol plus Water Mixtures at 298.15K

被引：13

作者：

Jimenez, Daniel M. ^{[1
]}

Cardenas, Zaira J. ^{[1
]}

Martinez, Fleming ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fis Quim, Cra 30 45-03, Bogota, Colombia

来源：

CHEMICAL ENGINEERING COMMUNICATIONS | 2016年 / 203卷 / 08期

关键词：

Apparent specific volume; Cosolvency; Lysine clonixinate; NIBS/R-K model; Procaine hydrochloride; Sodium naproxen; Solubility; COSOLVENT MIXTURES; SODIUM NAPROXEN; PROCAINE-HCL; DRUG SOLUBILITY; LIDOCAINE-HCL; AQUEOUS-SOLUTIONS; ETHANOL; PREDICTION; THERMODYNAMICS; MODELS;

D O I：

10.1080/00986445.2015.1131978

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The equilibrium solubility of three pharmaceutical salts, namely, sodium naproxen (Na.NAP), procaine hydrochloride (PC.HCl), and lysine clonixinate (Lys.Clon), was determined in propylene glycol (PG) + water mixtures at 298.15 K. If the mole fraction concentration scale is considered, the mixtures' composition-dependence on solubility was different for these drugs. Thus, the solubility of Na.NAP increased nonlinearly from pure water to pure PG. By contrast, the solubility of PC.HCl decreased nonlinearly from pure water to pure PG. In a different way, the solubility of Lys. Clon increased from pure water to the mixture with mass fraction of PG, w(1) = 0.80, and later, it decreased to reach a lower value in pure PG. A good correlation of the solubility data was obtained by using the modified NIBS/R-K model. Otherwise, the apparent specific volumes at saturation of these drugs were also calculated in all the mixtures under study.

引用

页码：1013 / 1019

页数：7

共 38 条

[1] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].