Rhodium-catalyzed asymmetric 1,4-addition and its related asymmetric reactions

被引:1360
作者
Hayashi, T [1 ]
Yamasaki, K [1 ]
机构
[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan
关键词
D O I
10.1021/cr020022z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents is developing quickly. The reaction can be carried out in an aqueous solvent and the enantioselectivity is very high, in most cases over 90% ee, at a reaction temperature of around 100°C. Thus, this reaction provides the best method for enantioselective introduction of aryl and alkenyl groups to β position of these electron deficient olefins.
引用
收藏
页码:2829 / 2844
页数:16
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