Alcohol and Metabolic-associated Fatty Liver Disease

The diagnosis of metabolic-associated fatty liver disease is based on the detection of liver steatosis together with the presence of metabolic dysfunction. According to this new defi-nition, the diagnosis of metabolic-associated fatty liver disease is independent of the amount of alcohol consumed. Actually, alcohol and its metabolites have various effects on metabolic-associated abnormalities during the process of alcohol me-tabolism. Studies have shown improved metabolic function in light to moderate alcohol drinkers. There are several studies focusing on the role of light to moderate alcohol intake on metabolic dysfunction. However, the results from studies are diverse, and the conclusions are often controversial. This re-view systematically discusses the effects of alcohol consump-tion, focusing on light to moderate alcohol consumption, on obesity, lipid and glucose metabolism, and blood pressure. Citation of this article: Sun FR, Wang BY. Alcohol and metabolic-associated fatty liver disease. J Clin Transl Hepa-tol 2021. doi: 10.14218/JCTH.2021.00173.