Hepatitis C virus infection and the dialysis patient

被引:55
作者
Fabrizi, Fabrizio [1 ]
Lunghi, Giovanna [1 ]
Ganeshan, Sri Venkatesh [1 ]
Martin, Paul [1 ]
Messa, Piergiorgio [1 ]
机构
[1] Osped Maggiore, IRCCS, Div Nephrol & Dialysis, Milan 20122, Italy
关键词
D O I
10.1111/j.1525-139X.2007.00311.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Hepatitis C virus(HCV) remains common in patients undergoing regular dialysis and is an important cause of liver disease in this population both during dialysis and after renal transplantation(RT). Anti-HCV screening of blood products has almost eliminated posttransfusion HCV infection but acquisition of HCV continues to occur in dialysis patients because of nosocomial spread. The natural history of HCV in dialysis population is not completely understood though recent data show that HCV infection has a detrimental role on survival of chronic dialysis patients. Several clinical trials have suggested that the response rate to conventional interferon (IFN) is higher in dialysis patients than those with normal kidney function but tolerance is lower. There are only limited data about pegylated IFN alone or in association with ribavirin for hepatitis C in dialysis population. IFN remains contraindicated post-RT because of concern about precipitating graft dysfunction; however, preliminary evidence shows the durability of sustained response to antiviral therapy pre-RT after renal transplant. Successful pretransplant therapy is associated with several benefits after RT including reduced incidence of posttransplant diabetes mellitus and de novo glomerulonephritis in HCV-infected recipients.
引用
收藏
页码:416 / 422
页数:7
相关论文
共 50 条
[31]   Spontaneous clearance or occult hepatitis C virus infection in dialysis patients [J].
Dzekova, Pavlina ;
Sikole, Aleksandar ;
Nikolov, Igor ;
Polenakovic, Momir .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 :97-97
[32]   Epidemiology of GB virus C/hepatitis G virus infection in patients on peritoneal dialysis [J].
Fabrizi, F ;
De Vecchi, AF ;
Lunghi, G ;
Finazzi, S ;
Bisegna, S ;
Ponticelli, C .
PERITONEAL DIALYSIS INTERNATIONAL, 2002, 22 (03) :405-410
[33]   Hepatitis C virus infection in the human immunodeficiency virus infected patient [J].
Clausen, Louise Nygaard ;
Lundbo, Lene Fogt ;
Benfield, Thomas .
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (34) :12132-12143
[34]   Hepatitis C virus infection in the human immunodeficiency virus infected patient [J].
Louise Nygaard Clausen ;
Lene Fogt Lundbo ;
Thomas Benfield .
World Journal of Gastroenterology, 2014, (34) :12132-12143
[35]   Hepatitis B virus infection in dialysis patients [J].
Fabrizi, F ;
Martin, P .
AMERICAN JOURNAL OF NEPHROLOGY, 2000, 20 (01) :1-11
[36]   Cutaneous Cryptococcosis in a Patient with Cirrhosis and Hepatitis C Virus Infection [J].
Miura, Takako ;
Kawakami, Yoshio ;
Otsuka, Mikio ;
Hachiya, Masahiro ;
Yamanoi, Takahiro ;
Ohashi, Kazutaka ;
Suzutani, Tatsuo ;
Yamamoto, Toshiyuki .
ACTA DERMATO-VENEREOLOGICA, 2010, 90 (01) :106-107
[37]   Patient acceptance of universal screening for hepatitis C virus infection [J].
Coffin, Phillip O. ;
Stevens, Anne M. ;
Scott, John D. ;
Stekler, Joanne D. ;
Golden, Matthew R. .
BMC INFECTIOUS DISEASES, 2011, 11
[38]   Pityriasis rosea in a patient with retrovirus infection and a history of syphilis and positive results of infection with hepatitis A virus, hepatitis B virus and hepatitis C virus [J].
Neneman, Anna ;
Mikiel, Dominik ;
Adamski, Zygmunt ;
Bowszyc-Dmochowska, Monika .
POSTEPY DERMATOLOGII I ALERGOLOGII, 2017, 34 (03) :276-278
[39]   Severe cryoglobulinemia in a patient with asymptomatic hepatitis C virus infection [J].
Iguchi, S ;
Toba, K ;
Fuse, I ;
Wada, Y ;
Maruyama, S ;
Takahashi, M ;
Koike, T ;
Nomoto, M ;
Shibata, A ;
Aizawa, Y .
INTERNAL MEDICINE, 1996, 35 (09) :712-716
[40]   New infection with heterotypic hepatitis C virus in a patient with long-term hepatitis C virus eradication [J].
De Mitri, MS ;
Cassini, R ;
Morsica, G ;
Bagaglio, S ;
Zoli, M ;
Bernardi, M .
DIGESTIVE AND LIVER DISEASE, 2001, 33 (07) :591-594