Low vitamin B6 levels and the risk of recurrent venous thromboembolism

被引：19

作者：

Hron, Gregor ^{[2
]}

Lombardi, Rossana ^{[3
]}

Eichinger, Sabine ^{[2
]}

Lecchi, Anna ^{[3
]}

Kyrle, Paul A. ^{[2
]}

Cattaneo, Marco ^{[1
]}

机构：

[1] Univ Milan, Osped San Paolo, Dipartimento Med Chirurgia & Odontoiatria, Unita Ematol & Trombosi, Milan, Italy

[2] Med Univ Vienna, Dept Internal Med 1, Vienna, Austria

[3] Univ Milan, IRCCS Fdn Osped Maggiore Mangiagalli & Regina Ele, Dipartimento Med & Specialita Med, Milan, Italy

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 09期

关键词：

deep vein thrombosis; risk factors; pulmonary embolism; homocysteine; vitamin B6;

D O I：

10.3324/haematol.11318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low plasma vitamin B6, measured as pyridoxal-5'-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE). In a prospective cohort of 757 patients with first VTE we investigated the association of PLP levels with risk of recurrent VTE. After 4 years, the likelihood of VTE recurrence was 22.5% (95% CI 13.6-31.5%) among patients with PLP <= 23.3 nmol/L and 14.4% (11.5-17.4%) among those with PLP >23.3 nmol/L (p=0.01). Patients with PLP <= 23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE.

引用

页码：1250 / 1253

页数：4

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