Fluorescence Detection and Dissociation of Amyloid-β Species for the Treatment of Alzheimer's Disease

被引：31
作者：
Lv, Guanglei [1 ]
Shen, Yang [1 ]
Zheng, Wubin [1 ]
Yang, Jiajia [1 ]
Li, Chunxia [1 ]
Lin, Jun [2 ]
机构：
[1] Zhejiang Normal Univ, Minist Educ Adv Catalysis Mat, Key Lab, Jinhua 321004, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
来源：
ADVANCED THERAPEUTICS | 2019年 / 2卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; fluorescence detection; photodynamic therapy; photothermal therapy; UP-CONVERSION NANOPARTICLES; VIVO PHOTODYNAMIC THERAPY; METAL-ORGANIC FRAMEWORK; SIZE-CONTROLLED SYNTHESIS; A-BETA; PHOTOTHERMAL THERAPY; PRECURSOR PROTEIN; IN-VITRO; SECONDARY NUCLEATION; HIGHLY EFFICIENT;
D O I：
10.1002/adtp.201900054
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disease. It is well established that the beta-amyloid peptide (A beta) species existing in several forms, such as soluble monomers, oligomers, and insoluble aggregates, play an essential role in the pathophysiology of AD. Therefore, much effort has been made to specifically detect A beta species and to inhibit A beta aggregation for the treatment of AD. In this review, an overview of recent advances in detecting different A beta forms mainly containing A beta aggregates, A beta oligomers, and A beta protofibrils is provided. In addition, photodynamic therapy (PDT) and photothermal therapy (PTT) are considered to be promising modalities for the treatment of AD because of the minimal invasiveness and high spatial selectivity. Herein, the strategies of inhibiting A beta aggregation and dissociating A beta aggregates using PDT, PTT, and A beta inhibitors for the treatment of AD are summarized.
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页数：15
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