Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose/high insulin

被引：2

作者：

Wang Mengxi ^{[1
]}

Liu Mo ^{[1
]}

Zhou Renjie ^{[2
]}

Wu Jing ^{[2
]}

Chen Dongya ^{[3
]}

Lei Hong ^{[1
]}

机构：

[1] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Key Lab Grains & Oils Qual Control & Proc, Nanjing, Jiangsu, Peoples R China

[2] Hefei Univ Technol, Sch Biol & Food Engn, Hefei, Anhui, Peoples R China

[3] Jiangsu Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2019年 / 32卷 / 06期

关键词：

Sesamin (SES); insulin resistance; L02; hepatocytes; insulin receptor; IRS/PI3K/Akt signaling pathway;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sesamin (SES) has the ameliorating effect on L02 hepatocyte model of insulin resistance induced by high glucose and high insulin, based on insulin receptor signaling pathway IRS/PI3K/Akt. Treatment with SES (200, 100 mu g/ml) increased glucose consumption, glucose uptake and the intracellular glycogen synthesis of L02 hepatocyte model of insulin resistance significantly. Moreover, treatment with SES promoted the gene and protein expression levels of insulin receptor (InsR) and the post-receptor associated proteins, such as insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), PI3K (phosphatidylinositol 3-kinase), GLUT4 (glucose transporter 4) significantly, which were determined by RT-PCR and immunoblot analysis. In conclusion, SES has the ameliorating effect on L02 hepatocyte model of insulin resistance induced by high glucose/high insulin, which might be related to its effect on promoting expression of insulin receptor and its associated proteins of IRS -PI3K-Akt passway, and thus promoting insulin sensitivity.

引用

页码：2733 / 2739

页数：7

共 19 条

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