Effects of polydatin on the proliferation, migration, and invasion of ovarian cancer

被引：6
作者：
Zhang, Xiuchun [1 ]
机构：
[1] Liaocheng Univ Hosp, Gynecol, Liaocheng 252000, Peoples R China
来源：
BIOCELL | 2019年 / 43卷 / 04期
关键词：
Polydatin; Ovarian cancer; Proliferation; Migration; Invasion; CELLS; APOPTOSIS;
D O I：
10.32604/biocell.2019.07973
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
To investigate the effects of polydatin on the proliferation, migration, and invasion of ovarian cancer, the change of proliferative ability, migration ability, and invasive ability of human ovarian cancer cell OVCAR-3, A2780, and HO-8910 was detected by using polydatin and up-regulating PI3K. The anticancer activity and mechanism of polydatin in ovarian cancer were analyzed. Polydatin could effectively inhibit the proliferation, migration, and invasion of OVCAR-3, A2780, and HO-8910, and inhibit the expression of PI3K protein. After the expression level of PI3K protein was up-regulated, the inhibitory effect of polydatin on the proliferative ability, migration ability, and invasive ability of OVCAR-3, A2780, and HO-8910 significantly decreased, suggesting that PI3K was the target of polydatin. Therefore, we concluded that polydatin could inhibit the proliferation, migration, and invasion of ovarian cancer cells by inhibiting the expression of PI3K protein, which provides an experimental basis for polydatin in the treatment of ovarian cancer.
引用
收藏
页码：313 / 319
页数：7
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