Effects of polydatin on the proliferation, migration, and invasion of ovarian cancer

被引：6
|
作者：
Zhang, Xiuchun [1 ]
机构：
[1] Liaocheng Univ Hosp, Gynecol, Liaocheng 252000, Peoples R China
来源：
BIOCELL | 2019年 / 43卷 / 04期
关键词：
Polydatin; Ovarian cancer; Proliferation; Migration; Invasion; CELLS; APOPTOSIS;
D O I：
10.32604/biocell.2019.07973
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
To investigate the effects of polydatin on the proliferation, migration, and invasion of ovarian cancer, the change of proliferative ability, migration ability, and invasive ability of human ovarian cancer cell OVCAR-3, A2780, and HO-8910 was detected by using polydatin and up-regulating PI3K. The anticancer activity and mechanism of polydatin in ovarian cancer were analyzed. Polydatin could effectively inhibit the proliferation, migration, and invasion of OVCAR-3, A2780, and HO-8910, and inhibit the expression of PI3K protein. After the expression level of PI3K protein was up-regulated, the inhibitory effect of polydatin on the proliferative ability, migration ability, and invasive ability of OVCAR-3, A2780, and HO-8910 significantly decreased, suggesting that PI3K was the target of polydatin. Therefore, we concluded that polydatin could inhibit the proliferation, migration, and invasion of ovarian cancer cells by inhibiting the expression of PI3K protein, which provides an experimental basis for polydatin in the treatment of ovarian cancer.
引用
收藏
页码：313 / 319
页数：7
相关论文
共 50 条
  • [1] Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian Cancer Cells
    Li Mo Juan
    Xiong Dan
    Huang Hao
    Wen Zhong Yong
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2021, 34 (02) : 139 - +
  • [2] CINOBUFOTALIN INHIBITS OVARIAN CANCER CELLS PROLIFERATION, MIGRATION AND INVASION
    McDowell, A. B., Jr.
    McCormick, T. C.
    Kuehl, T. J.
    Uddin, M. N.
    Co, M.
    Beeram, M. R.
    Uddin, M. N.
    Afroze, S. H.
    Zawieja, D. C.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2015, 63 (04) : 684 - 684
  • [3] Cinobufotalin Inhibits Ovarian Cancer Cells Proliferation, Migration and Invasion
    Afroze, Syeda
    Co, Mary Antonette
    McDowell, Anthony
    McCormick, Timothy
    Beeram, Madhava
    Zawieja, David
    Kuehl, Thomas
    Uddin, Mohammad
    FASEB JOURNAL, 2015, 29
  • [4] Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian Cancer Cells
    LI Mo Juan
    XIONG Dan
    HUANG Hao
    WEN Zhong Yong
    BiomedicalandEnvironmentalSciences, 2021, 34 (02) : 139 - 151
  • [5] PUM1 promotes ovarian cancer proliferation, migration and invasion
    Guan, Xue
    Chen, Shuo
    Liu, Yao
    Wang, Li-li
    Zhao, Yang
    Zong, Zhi-Hong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 497 (01) : 313 - 318
  • [6] Role of pterostilbene on proliferation, invasion, and migration in ovarian and uterine cancer cells
    Lowe, Gina
    Wen, Wei
    Roberts, Cai
    Finlay, James
    Glackin, Carlotta
    Han, Ernest
    Dellinger, Thanh H.
    CANCER RESEARCH, 2014, 74 (19)
  • [7] Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma
    Jiao, Yang
    Wu, Yan
    Du, Dong
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2018, 51 (04)
  • [8] Effects of silencing hsa_circ_0015326 on proliferation, migration, invasion, and apoptosis of epithelial ovarian cancer cells
    Zhang, Cui-Ying
    Liu, Wei
    Wang, Jia
    Zhang, Wen-Wen
    Huang, Jing-Lin
    Huang, Xi-Yue
    Zhang, Ying-Feng
    Li, Chang-Jiang
    Wang, Ting-Ting
    Mao, Yan-Hua
    Wang, Wen-Min
    Sun, Cong-Cong
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2024, 38 (04)
  • [9] Effects of Flavonoids from Potamogeton crispus L. on Proliferation, Migration, and Invasion of Human Ovarian Cancer Cells
    Du, Yuanda
    Feng, Jinhong
    Wang, Renqing
    Zhang, Haijie
    Liu, Jian
    PLOS ONE, 2015, 10 (06):
  • [10] In vitro effect of lysophosphatidic acid on proliferation, invasion and migration of human ovarian cancer cells
    Wang, Qingfu
    Zhu, Lixin
    Qin, Aiping
    Chen, Tiefeng
    Li, Jinpen
    Wu, Beitai
    Xiao, Yu
    Lai, Zongan
    Xie, Weixiong
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (02) : 219 - 224
12345