Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects

被引：6
|
作者：
Chen, Biao [1 ,2 ]
Zhang, Yajun [2 ,3 ]
Yang, Yaning [1 ,2 ]
Chen, Shaopeng [2 ,3 ]
Xu, An [1 ,2 ,3 ]
Wu, Lijun [1 ,2 ,3 ,4 ]
Xu, Shengmin [2 ,3 ]
机构：
[1] Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
[3] Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
[4] Anhui Univ, Inst Phys & Informat Technol, Hefei 230601, Anhui, Peoples R China
来源：
NANOMEDICINE | 2018年 / 13卷 / 16期
基金：
中国国家自然科学基金;
关键词：
anticancer effects; radiosensitivity; silver nanoparticles; telomerase; telomere; G-QUADRUPLEX; DNA-DAMAGE; HISTONE H3; EXPRESSION; PROMOTES; PHOSPHORYLATION; MECHANISMS; SENESCENCE; TOXICITY; EXPOSURE;
D O I：
10.2217/nnm-2018-0036
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To investigate the possible mechanisms of telomerase and telomere underlying the anticancer effects of silver nanoparticles (AgNPs). Materials & methods: 25nm polyvinylpyrrolidone-coated AgNPs were used. The telomerase activity and telomere function were evaluated. The anticancer effects of AgNPs were gauged with cell viability assay under different statement of telomerase and telomere. Results & conclusion: AgNPs could inhibit telomerase activity and lead to telomere shortening and dysfunction. Overexpression of telomerase attenuated the anticancer activity of AgNPs, whereas downregulation of telomerase activity or dysfunction of the telomere enhanced the cytotoxicity of AgNPs in HeLa cells. Our findings provided strong evidence that the anticancer effects of AgNPs were mediated via interference with the telomerase/telomere.
引用
收藏
页码：2067 / 2082
页数：16
相关论文
共 50 条
  • [41] Silver Nanoparticles Derived by Artemisia arborescens Reveal Anticancer and Apoptosis-Inducing Effects
    Bordoni, Valentina
    Sanna, Luca
    Lyu, Weidong
    Avitabile, Elisabetta
    Zoroddu, Stefano
    Medici, Serenella
    Kelvin, David J.
    Bagella, Luigi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [42] Effects of silver nanoparticles on rat hepatic cytochrome P450 enzyme activity
    Kulthong, Kornphimol
    Maniratanachote, Rawiwan
    Kobayashi, Yuki
    Fukami, Tatsuki
    Yokoi, Tsuyoshi
    XENOBIOTICA, 2012, 42 (09) : 854 - 862
  • [43] Effects of Silver Nanoparticles on Ctenopharyngodon idella: Synthesis, Characterization, Antibacterial Activity, and Toxicological Assessment
    Kakakhel, Mian Adnan
    Jamil, Arshad
    Narwal, Nishita
    MICROSCOPY RESEARCH AND TECHNIQUE, 2025, 88 (03) : 686 - 695
  • [44] The Effects of Mindfulness-Based Interventions on Telomere Length and Telomerase Activity: A Systematic Review and Meta-Analysis
    Bossert, Lukas
    Arzberger, Karla
    Dorok, Fabian
    Kern, Julia
    Stickler, Charlotte
    Wunderlich, Maximilian
    Tran, Ulrich S.
    MINDFULNESS, 2023, 14 (03) : 495 - 509
  • [45] Contact-independent suppressive activity of regulatory T cells is associated with telomerase inhibition, telomere shortening and target lymphocyte apoptosis
    Zhdanov, Dmitry D.
    Gladilina, Yulia A.
    Grishin, Dmitry V.
    Grachev, Vladimir A.
    Orlova, Valentina S.
    Pokrovskaya, Marina V.
    Alexandrova, Svetlana S.
    Pokrovsky, Vadim S.
    Sokolov, Nikolai N.
    MOLECULAR IMMUNOLOGY, 2018, 101 : 229 - 244
  • [46] Effects of Silver Nanoparticles on Soil Enzyme Activity of Different Wetland Plant Soil Systems
    Cao, Chong
    Huang, Juan
    Cai, Wen-Shu
    Yan, Chun-Ni
    Liu, Jia-Liang
    Jiang, Yao-Dong
    SOIL & SEDIMENT CONTAMINATION, 2017, 26 (05): : 558 - 567
  • [47] Effects of silver sulfide nanoparticles on the microbial community structure and biological activity of freshwater biofilms
    Liu, Songqi
    Wang, Chao
    Hou, Jun
    Wang, Peifang
    Miao, Lingzhan
    Li, Tengfei
    ENVIRONMENTAL SCIENCE-NANO, 2018, 5 (12) : 2899 - 2908
  • [48] Bio-inspired synthesis of silver nanoparticles and their nanocomposites for antibacterial and anticancer activity: A comparative study
    Balaji, V.
    Perumal, Sakthivel
    Palanisamy, Subramanian
    Karuppaiah, M.
    Asaithambi, S.
    Velauthapillai, Dhayalan
    Kumar, P.
    Yuvakkumar, R.
    Ravi, G.
    JOURNAL OF ALLOYS AND COMPOUNDS, 2023, 966
  • [49] Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity
    Jain, Nancy
    Jain, Priyanshu
    Rajput, Devyani
    Patil, Umesh Kumar
    MICRO AND NANO SYSTEMS LETTERS, 2021, 9 (01)
  • [50] Reducing the cytotoxicity while improving the anticancer activity of silver nanoparticles through α-tocopherol succinate modification
    Hu, Guansong
    Cai, Yuchun
    Tu, Zhengchao
    Luo, Jinfeng
    Qiao, Xueliang
    Chen, Qingyuan
    Zhang, Wanzhong
    RSC ADVANCES, 2015, 5 (100) : 82050 - 82055
12345