Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects

被引：6
|
作者：
Chen, Biao [1 ,2 ]
Zhang, Yajun [2 ,3 ]
Yang, Yaning [1 ,2 ]
Chen, Shaopeng [2 ,3 ]
Xu, An [1 ,2 ,3 ]
Wu, Lijun [1 ,2 ,3 ,4 ]
Xu, Shengmin [2 ,3 ]
机构：
[1] Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
[3] Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
[4] Anhui Univ, Inst Phys & Informat Technol, Hefei 230601, Anhui, Peoples R China
来源：
NANOMEDICINE | 2018年 / 13卷 / 16期
基金：
中国国家自然科学基金;
关键词：
anticancer effects; radiosensitivity; silver nanoparticles; telomerase; telomere; G-QUADRUPLEX; DNA-DAMAGE; HISTONE H3; EXPRESSION; PROMOTES; PHOSPHORYLATION; MECHANISMS; SENESCENCE; TOXICITY; EXPOSURE;
D O I：
10.2217/nnm-2018-0036
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To investigate the possible mechanisms of telomerase and telomere underlying the anticancer effects of silver nanoparticles (AgNPs). Materials & methods: 25nm polyvinylpyrrolidone-coated AgNPs were used. The telomerase activity and telomere function were evaluated. The anticancer effects of AgNPs were gauged with cell viability assay under different statement of telomerase and telomere. Results & conclusion: AgNPs could inhibit telomerase activity and lead to telomere shortening and dysfunction. Overexpression of telomerase attenuated the anticancer activity of AgNPs, whereas downregulation of telomerase activity or dysfunction of the telomere enhanced the cytotoxicity of AgNPs in HeLa cells. Our findings provided strong evidence that the anticancer effects of AgNPs were mediated via interference with the telomerase/telomere.
引用
收藏
页码：2067 / 2082
页数：16
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