Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects

被引：6
|
作者：
Chen, Biao [1 ,2 ]
Zhang, Yajun [2 ,3 ]
Yang, Yaning [1 ,2 ]
Chen, Shaopeng [2 ,3 ]
Xu, An [1 ,2 ,3 ]
Wu, Lijun [1 ,2 ,3 ,4 ]
Xu, Shengmin [2 ,3 ]
机构：
[1] Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
[3] Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
[4] Anhui Univ, Inst Phys & Informat Technol, Hefei 230601, Anhui, Peoples R China
来源：
NANOMEDICINE | 2018年 / 13卷 / 16期
基金：
中国国家自然科学基金;
关键词：
anticancer effects; radiosensitivity; silver nanoparticles; telomerase; telomere; G-QUADRUPLEX; DNA-DAMAGE; HISTONE H3; EXPRESSION; PROMOTES; PHOSPHORYLATION; MECHANISMS; SENESCENCE; TOXICITY; EXPOSURE;
D O I：
10.2217/nnm-2018-0036
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To investigate the possible mechanisms of telomerase and telomere underlying the anticancer effects of silver nanoparticles (AgNPs). Materials & methods: 25nm polyvinylpyrrolidone-coated AgNPs were used. The telomerase activity and telomere function were evaluated. The anticancer effects of AgNPs were gauged with cell viability assay under different statement of telomerase and telomere. Results & conclusion: AgNPs could inhibit telomerase activity and lead to telomere shortening and dysfunction. Overexpression of telomerase attenuated the anticancer activity of AgNPs, whereas downregulation of telomerase activity or dysfunction of the telomere enhanced the cytotoxicity of AgNPs in HeLa cells. Our findings provided strong evidence that the anticancer effects of AgNPs were mediated via interference with the telomerase/telomere.
引用
收藏
页码：2067 / 2082
页数：16
相关论文
共 50 条
  • [1] Inhibition of autophagy enhances the anticancer activity of silver nanoparticles
    Lin, Jun
    Huang, Zhihai
    Wu, Hao
    Zhou, Wei
    Jin, Peipei
    Wei, Pengfei
    Zhang, Yunjiao
    Zheng, Fang
    Zhang, Jiqian
    Xu, Jing
    Hu, Yi
    Wang, Yanhong
    Li, Yajuan
    Gu, Ning
    Wen, Longping
    AUTOPHAGY, 2014, 10 (11) : 2006 - 2020
  • [2] Correlation of chemosensitivity to anticancer drugs and telomere length, telomerase activity and telomerase RNA expression in human ovarian cancer cells
    Kiyozuka, Y
    Yamamoto, D
    Yang, JH
    Uemura, Y
    Senzaki, H
    Adachi, S
    Tsubura, A
    ANTICANCER RESEARCH, 2000, 20 (1A) : 203 - 212
  • [3] Effects of ionizing radiation on telomere length and telomerase activity in cultured human lens epithelium cells
    Bains, Savneet Kaur
    Chapman, Kim
    Bright, Scott
    Senan, Anish
    Kadhim, Munira
    Slijepcevic, Predrag
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2018, 95 (01) : 54 - 63
  • [4] Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant
    Delhommeau, FO
    Thierry, A
    Feneux, D
    Lauret, E
    Leclercq, E
    Courtier, MH
    Sainteny, F
    Vainchenker, W
    Bennaceur-Griscelli, A
    ONCOGENE, 2002, 21 (54) : 8262 - 8271
  • [5] Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant
    François Delhommeau
    Antoine Thierry
    Danièle Feneux
    Evelyne Lauret
    Edwige Leclercq
    Marie Hélène Courtier
    Françoise Sainteny
    William Vainchenker
    Annelise Bennaceur-Griscelli
    Oncogene, 2002, 21 : 8262 - 8271
  • [6] Telomere length, telomerase activity and telomerase RNA expression in human esophageal cancer cells: Correlation with cell proliferation, differentiation and chemosensitivity to anticancer drugs
    Asai, A
    Kiyozuka, Y
    Yoshida, R
    Fujii, T
    Hioki, K
    Tsubura, A
    ANTICANCER RESEARCH, 1998, 18 (3A) : 1465 - 1472
  • [7] Telomerase Activity and Telomere Length in Human Tumor Cells with Acquired Resistance to Anticancer Agents
    Smith, V.
    Dai, F.
    Spitz, M.
    Peters, G. J.
    Fiebig, H. H.
    Hussain, A.
    Burger, A. M.
    JOURNAL OF CHEMOTHERAPY, 2009, 21 (05) : 542 - 549
  • [8] Anticancer effects of silver nanoparticles encapsulated by Taxus baccata extracts
    Kajani, Abolghasem Abbasi
    Zarkesh-Esfahani, Sayyed Hamid
    Bordbar, Abdol-Khalegh
    Khosropour, Ahmad Reza
    Razmjou, Amir
    Kardi, Mohammad
    JOURNAL OF MOLECULAR LIQUIDS, 2016, 223 : 549 - 556
  • [9] PEG capped methotrexate silver nanoparticles for efficient anticancer activity and biocompatibility
    Muhammad, Zarmina
    Raza, Abida
    Ghafoor, Sana
    Naeem, Ayesha
    Naz, Syeda Sohaila
    Riaz, Sundus
    Ahmed, Wajiha
    Rana, Nosheen Fatima
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 91 : 251 - 255
  • [10] Antibacterial Activity of Silver Nanoparticles: Structural Effects
    Tang, Shaoheng
    Zheng, Jie
    ADVANCED HEALTHCARE MATERIALS, 2018, 7 (13)
12345