Modulation of K+ channel currents by serum amineoxidase in neurons

被引：22

作者：

Wu, LY

Mateescu, MA

Wang, XT

Mondovi, B

Wang, R

机构：

[1] UNIV MONTREAL,HOP SACRE COEUR,DEPT PHYSIOL,MONTREAL,PQ H3C 3J7,CANADA

[2] UNIV MONTREAL,HOP SACRE COEUR,RES CTR,MONTREAL,PQ H3C 3J7,CANADA

[3] UNIV QUEBEC,DEPT CHEM BIOCHEM,MONTREAL,PQ H3C 3P8,CANADA

[4] UNIV ROMA LA SAPIENZA,CTR BIOL MOLEC,DEPT BIOCHEM SCI,I-00185 ROME,ITALY

[5] UNIV ROMA LA SAPIENZA,CTR BIOL MOLEC,CNR,I-00185 ROME,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 220卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/bbrc.1996.0354

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of bovine serum amineoxidase (SAG), a circulating copper-enzyme, on neuronal K+ channels is described. Bovine SAO enhanced K+ channel currents in NIE-115 neuroblastoma cells in a time-dependent manner. Unlike ceruloplasmin (another copper-protein, shown as depolarizing factor in neurons), SAO had no effect on resting potential of neurons. However, pretreatment of cells with SAO inhibited ceruloplasmin-induced membrane depolarization. Although ceruloplasmin alone inhibited K+ channel currents, ii further enhanced K+ channel currents in the presence of SAG. Therefore, SAO may be another endogenous modulator of neuronal K+ channels with effect and mechanisms different from those of ceruloplasmin. (C) 1996 Academic Press, Inc.

引用

页码：47 / 52

页数：6

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