Association between anti-β2 glycoprotein I antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: a prospective study of 155 cases

被引：39
作者：
Shen, Y. [1 ]
Chen, X-W [1 ]
Sun, C-Y [1 ]
Dai, M. [1 ]
Yan, Y-C [2 ]
Yang, C-D [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Rheumatol, Shanghai 200001, Peoples R China
[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Nephrol, Shanghai 200001, Peoples R China
来源：
LUPUS | 2010年 / 19卷 / 10期
基金：
中国国家自然科学基金;
关键词：
anti-beta 2 glycoprotein I antibodies; C4d; glomerular microthrombosis; lupus nephritis; ANTIPHOSPHOLIPID SYNDROME; THROMBOTIC MICROANGIOPATHY; COMPLEMENT ACTIVATION; ERYTHEMATOSUS; CLASSIFICATION; GLOMERULONEPHRITIS; ANTICARDIOLIPIN; PREVALENCE; CRITERIA; CELLS;
D O I：
10.1177/0961203310368409
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT is still unknown. In our previous study, we found that the level of IgG anti-beta 2 glycoprotein I (beta 2GPI) antibodies was higher in the LN-GMT group than in the LN-non-GMT group, which indicated that anti-beta 2GPI antibodies may play a role in GMT formation. Many studies have demonstrated that the activation of the classical complement pathway may play a critical role in fetal loss and aPL-induced thrombosis formation. To investigate whether complement activation plays a role in GMT formation and to evaluate its relationship with aPL, we prospectively investigated deposition of C4d in 155 renal biopsy specimens of LN patients. The results revealed a strong relationship between the intensity of glomerular C4d staining and the presence of microthrombi (p < 0.001). The detection rate of IgG anti-beta 2GPI antibodies was higher in the LN-GMT group than in the LN-non-GMT group (p < 0.05). Further, the intensity of glomerular C4d staining was significantly related with IgG anti-beta 2GPI antibodies (p < 0.05). The results of our study suggest that anti-beta 2GPI antibodies may play a role in GMT formation, and this process might involve complement activation. Lupus (2010) 19, 1195-1203.
引用
收藏
页码：1195 / 1203
页数：9
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