Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections

被引：56
作者：
Koganti, Raghuram [1 ]
Yadavalli, Tejabhiram [1 ]
Shukla, Deepak [1 ,2 ]
机构：
[1] Univ Illinois, Dept Ophthalmol & Visual Sci, 1855 W Taylor St, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA
来源：
MICROORGANISMS | 2019年 / 7卷 / 10期
基金：
美国国家卫生研究院;
关键词：
herpes simplex virus; herpesvirus; keratitis; ocular therapy; antiviral; acyclovir; HEPARAN-SULFATE; DRUG-RESISTANCE; EYE DISEASE; CELL-FUSION; VIRAL ENTRY; ACYCLOVIR; PROTEIN; PEPTIDE; REPLICATION; KERATITIS;
D O I：
10.3390/microorganisms7100429
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Herpes simplex virus type-1 (HSV-1) is a neurotropic, double-stranded DNA virus that can cause a wide variety of diseases, including many ocular pathologies. It is one of the leading causes of infectious blindness in the United States. Because of its ubiquitous nature and its potential to cause serious ocular maladies, there is a significant need for more effective antiviral therapies against ocular HSV-1. In this review, we discuss the lifecycle of HSV-1 as it pertains to corneal infections and the clinically approved as well as emerging treatments to combat HSV-1 infections. We also highlight some newly identified host targets for the antiviral drug development.
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页数：16
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