Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications

被引:30
作者
Man, Andy W. C. [1 ]
Zhou, Yawen [1 ]
Xia, Ning [1 ]
Li, Huige [1 ]
机构
[1] Johannes Gutenberg Univ Mainz, Med Ctr, Dept Pharmacol, D-55131 Mainz, Germany
关键词
perivascular adipose tissue; oxidative stress; sirtuin; 1; endothelial nitric oxide synthase; metabolic diseases; cardiovascular diseases; VASCULAR ENDOTHELIAL-CELLS; ADIPOKINE GENE-EXPRESSION; RENIN-ANGIOTENSIN SYSTEM; INDUCED OXIDATIVE STRESS; RECEPTOR-GAMMA DELETION; NITRIC-OXIDE SYNTHASE; FAT DIET ROLE; HYDROGEN-SULFIDE; PROINFLAMMATORY PHENOTYPE; MITOCHONDRIAL DYSFUNCTION;
D O I
10.3390/antiox9070574
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Perivascular adipose tissue (PVAT) is the connective tissue surrounding most of the systemic blood vessels. PVAT is now recognized as an important endocrine tissue that maintains vascular homeostasis. Healthy PVAT has anticontractile, anti-inflammatory, and antioxidative roles. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. Accumulating data from both humans and experimental animal models suggests that PVAT dysfunction is potentially linked to cardiovascular diseases, and associated with augmented vascular inflammation, oxidative stress, and arterial remodeling. Reactive oxygen species produced from PVAT can be originated from mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and uncoupled endothelial nitric oxide synthase. PVAT can also sense vascular paracrine signals and response by secreting vasoactive adipokines. Therefore, PVAT may constitute a novel therapeutic target for the prevention and treatment of cardiovascular diseases. In this review, we summarize recent findings on PVAT functions, ROS production, and oxidative stress in different pathophysiological settings and discuss the potential antioxidant therapies for cardiovascular diseases by targeting PVAT.
引用
收藏
页码:1 / 25
页数:25
相关论文
共 172 条
[1]   Health Effects of Overweight and Obesity in 195 Countries over 25 Years [J].
Afshin, Ashkan ;
Forouzanfar, Mohammad H. ;
Reitsma, Marissa B. ;
Sur, Patrick ;
Estep, Kara ;
Lee, Alex ;
Marczak, Laurie ;
Mokdad, Ali H. ;
Moradi-Lakeh, Maziar ;
Naghavi, Mohsen ;
Salama, Joseph S. ;
Vos, Theo ;
Abate, Kalkidan H. ;
Abbafati, Cristiana ;
Ahmed, Muktar B. ;
Al-Aly, Ziyad ;
Alkerwi, Ala'a ;
Al-Raddadi, Rajaa ;
Amare, Azmeraw T. ;
Amberbir, Alemayehu ;
Amegah, Adeladza K. ;
Amini, Erfan ;
Amrock, Stephen M. ;
Anjana, Ranjit M. ;
Arnlov, Johan ;
Asayesh, Hamid ;
Banerjee, Amitava ;
Barac, Aleksandra ;
Baye, Estifanos ;
Bennett, Derrick A. ;
Beyene, Addisu S. ;
Biadgilign, Sibhatu ;
Biryukov, Stan ;
Bjertness, Espen ;
Boneya, Dube J. ;
Campos-Nonato, Ismael ;
Carrero, Juan J. ;
Cecilio, Pedro ;
Cercy, Kelly ;
Ciobanu, Liliana G. ;
Cornaby, Leslie ;
Damtew, Solomon A. ;
Dandona, Lalit ;
Dandona, Rakhi ;
Dharmaratne, Samath D. ;
Duncan, Bruce B. ;
Eshrati, Babak ;
Esteghamati, Alireza ;
Feigin, Valery L. ;
Fernandes, Joao C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (01) :13-27
[2]   Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice [J].
Agabiti-Rosei, Claudia ;
Favero, Gaia ;
De Ciuceis, Carolina ;
Rossini, Claudia ;
Porteri, Enzo ;
Rodella, Luigi Fabrizio ;
Franceschetti, Lorenzo ;
Sarkar, Anna Maria ;
Agabiti-Rosei, Enrico ;
Rizzoni, Damiano ;
Rezzani, Rita .
HYPERTENSION RESEARCH, 2017, 40 (01) :41-50
[3]  
Agha M, 2017, INT J SURG-ONCOL, V2, DOI [10.1097/IJ9.0000000000000017, 10.1097/IJ9.0000000000000019]
[4]   Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure [J].
Aghamohammadzadeh, Reza ;
Unwin, Richard D. ;
Greenstein, Adam S. ;
Heagerty, Anthony M. .
JOURNAL OF VASCULAR RESEARCH, 2015, 52 (05) :299-305
[5]   DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats [J].
Alam, Md. Ashraful ;
Chowdhury, Mohammed Riaz Hasan ;
Jain, Preeti ;
Sagor, Md. Abu Taher ;
Reza, Hasan Mahmud .
DIABETOLOGY & METABOLIC SYNDROME, 2015, 7
[6]   Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity [J].
Alcala, Martin ;
Sanchez-Vera, Isabel ;
Sevillano, Julio ;
Herrero, Laura ;
Serra, Dolors ;
Pilar Ramos, M. ;
Viana, Marta .
OBESITY, 2015, 23 (08) :1598-1606
[7]  
Aldiss P., 2019, BIORXIV
[8]   'Browning' the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk [J].
Aldiss, Peter ;
Davies, Graeme ;
Woods, Rachel ;
Budge, Helen ;
Sacks, Harold S. ;
Symonds, Michael E. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 228 :265-274
[9]   High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion [J].
Almabrouk, Tarek A. M. ;
White, Anna D. ;
Ugusman, Azizah B. ;
Skiba, Dominik S. ;
Katwan, Omar J. ;
Alganga, Husam ;
Guzik, Tomasz J. ;
Touyz, Rhian M. ;
Salt, Ian P. ;
Kennedy, Simon .
FRONTIERS IN PHYSIOLOGY, 2018, 9
[10]   Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue [J].
Antonopoulos, Alexios S. ;
Margaritis, Marios ;
Coutinho, Patricia ;
Shirodaria, Cheerag ;
Psarros, Costas ;
Herdman, Laura ;
Sanna, Fabio ;
De Silva, Ravi ;
Petrou, Mario ;
Sayeed, Rana ;
Krasopoulos, George ;
Lee, Regent ;
Digby, Janet ;
Reilly, Svetlana ;
Bakogiannis, Constantinos ;
Tousoulis, Dimitris ;
Kessler, Benedikt ;
Casadei, Barbara ;
Channon, Keith M. ;
Antoniades, Charalambos .
DIABETES, 2015, 64 (06) :2207-2219