Salmonella spp. survival strategies within the host gastrointestinal tract

被引:83
作者
Alvarez-Ordonez, Avelino [1 ,2 ]
Begley, Maire [1 ]
Prieto, Miguel [3 ]
Messens, Winy [4 ]
Lopez, Mercedes [3 ]
Bernardo, Ana [3 ]
Hill, Colin [1 ,2 ]
机构
[1] Univ Coll Cork, Dept Microbiol, Cork, Ireland
[2] Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland
[3] Univ Leon, Fac Vet, Dept Food Hyg & Technol, E-24071 Leon, Spain
[4] EFSA, Biol Hazards BIOHAZ Unit, I-43121 Parma, Italy
来源
MICROBIOLOGY-SGM | 2011年 / 157卷
关键词
ENTERICA SEROVAR TYPHIMURIUM; ACID TOLERANCE RESPONSE; ESCHERICHIA-COLI; BILE RESISTANCE; TRANSCRIPTIONAL REGULATION; GASTRIC-ACID; LYSINE DECARBOXYLASE; MUTANTS DEFICIENT; BIOFILM FORMATION; GLOBAL REGULATOR;
D O I
10.1099/mic.0.050351-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human salmonellosis infections are usually acquired via the food chain as a result of the ability of Salmonella serovars to colonize and persist within the gastrointestinal tract of their hosts. In addition, after food ingestion and in order to cause foodborne disease in humans, Salmonella must be able to resist several deleterious stress conditions which are part of the host defence against infections. This review gives an overview of the main defensive mechanisms involved in the Salmonella response to the extreme acid conditions of the stomach, and the elevated concentrations of bile salts, osmolytes and commensal bacterial metabolites, and the low oxygen tension conditions of the mammalian and avian gastrointestinal tracts.
引用
收藏
页码:3268 / 3281
页数:14
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