Response to Second Generation Antipsychotics in Youth with Comorbid Bipolar Disorder and Autism Spectrum Disorder

被引：24
|
作者：
Joshi, Gagan [1 ,2 ]
Biederman, Joseph [2 ]
Wozniak, Janet [2 ]
Doyle, Robert [2 ]
Hammerness, Paul [2 ]
Galdo, Maribel
Sullivan, Nora
Williams, Courtney
Brethel, Kristin
Woodworth, K. Yvonne
Mick, Eric [2 ]
机构：
[1] Massachusetts Gen Hosp, Pediat Psychopharmacol Res Program, Pediat Psychopharmacol Res Dept, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2012年 / 18卷 / 01期
关键词：
Autism spectrum disorder (ASD); bipolar disorder (BPD); comorbid; DOUBLE-BLIND; RATING-SCALE; OPEN-LABEL; INFANTILE-AUTISM; CHILDREN; RISPERIDONE; PLACEBO; MANIA; ADOLESCENTS; ARIPIPRAZOLE;
D O I：
10.1111/j.1755-5949.2010.00219.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective: To assess the impact of comorbid autism spectrum disorders (ASD) on the response to second-generation antipsychotics (SGA) in pediatric bipolar disorder (BPD). Methods: Secondary analysis of identically designed 8-week open-label trials of SGA monotherapy (risperidone, olanzapine, quetiapine, ziprasidone, or aripiprazole) in youth with BPD. Results: Of the 151 BPD subjects 15% (n= 23) met criteria for comorbid ASD. There were no differences in the rate of antimanic response (YMRS change =30% or CGI-Improvement =2: 65% vs. 69%; P= 0.7) in the presence of comorbid ASD. Conclusion: No difference observed in the rate of antimanic response or tolerability to SGA monotherapy in the presence of ASD comorbidity.
引用
收藏
页码：28 / 33
页数：6
相关论文
共 50 条
  • [41] Antipsychotics and bipolar disorder
    不详
    PROGRESS IN NEUROLOGY AND PSYCHIATRY, 2007, 11 (09) : 41 - 41
  • [42] Antipsychotics in bipolar disorder
    Gelenberg, AJ
    Hopkins, HS
    JOURNAL OF CLINICAL PSYCHIATRY, 1996, 57 : 49 - 52
  • [43] Antipsychotics in bipolar disorder
    Licht, RW
    NORDIC JOURNAL OF PSYCHIATRY, 2000, 54 : 26 - 26
  • [44] COMORBID BIPOLAR DISORDER AND CONDUCT DISORDER
    Yule, Amy
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2023, 62 (10): : S329 - S330
  • [45] MANAGEMENT OF ADHD IN INDIVIDUALS WITH COMORBID AUTISM SPECTRUM DISORDER
    Henriksson, Linda Halldner
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2021, 60 (10): : S50 - S50
  • [46] UNDERSTANDING COMORBID SYMPTOM DIMENSIONS IN AUTISM SPECTRUM DISORDER
    Volkmar, Fred Robert
    McDougle, Christopher J.
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2017, 56 (10): : S8 - S9
  • [47] Safety and Efficacy of Second-Generation Antipsychotics in Autism Spectrum Disorder: A Systematic Review and Network Meta-Analysis
    Nagem Lopes, Luis Philipe
    Lima, Elisangela Costa
    Mazzei, Lauren Giustti
    Bergamaschi, Cristiane
    Silva, Jessica
    Oliveira, Jardel Correa
    Lopes, Luciane Cruz
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2024, 33 : 293 - 293
  • [48] Comorbid psychopathology with autism spectrum disorder in children: An overview
    Matson, Johnny L.
    Nebel-Schwalm, Marie S.
    RESEARCH IN DEVELOPMENTAL DISABILITIES, 2007, 28 (04) : 341 - 352
  • [49] Adherence, Persistence of Use, and Costs Associated With Second-Generation Antipsychotics for Bipolar Disorder
    Rascati, Karen L.
    Richards, Kristin M.
    Ott, Carol A.
    Goddard, Andrew W.
    Stafkey-Mailey, Dana
    Alvir, Jose
    Sanders, Kafi N.
    Mychaskiw, Marko
    PSYCHIATRIC SERVICES, 2011, 62 (09) : 1032 - 1040
  • [50] Achieving success across the comorbid spectrum in bipolar disorder
    Vieta, E
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2005, 15 : S658 - S658
12345