Response to Second Generation Antipsychotics in Youth with Comorbid Bipolar Disorder and Autism Spectrum Disorder

被引：24
|
作者：
Joshi, Gagan [1 ,2 ]
Biederman, Joseph [2 ]
Wozniak, Janet [2 ]
Doyle, Robert [2 ]
Hammerness, Paul [2 ]
Galdo, Maribel
Sullivan, Nora
Williams, Courtney
Brethel, Kristin
Woodworth, K. Yvonne
Mick, Eric [2 ]
机构：
[1] Massachusetts Gen Hosp, Pediat Psychopharmacol Res Program, Pediat Psychopharmacol Res Dept, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2012年 / 18卷 / 01期
关键词：
Autism spectrum disorder (ASD); bipolar disorder (BPD); comorbid; DOUBLE-BLIND; RATING-SCALE; OPEN-LABEL; INFANTILE-AUTISM; CHILDREN; RISPERIDONE; PLACEBO; MANIA; ADOLESCENTS; ARIPIPRAZOLE;
D O I：
10.1111/j.1755-5949.2010.00219.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective: To assess the impact of comorbid autism spectrum disorders (ASD) on the response to second-generation antipsychotics (SGA) in pediatric bipolar disorder (BPD). Methods: Secondary analysis of identically designed 8-week open-label trials of SGA monotherapy (risperidone, olanzapine, quetiapine, ziprasidone, or aripiprazole) in youth with BPD. Results: Of the 151 BPD subjects 15% (n= 23) met criteria for comorbid ASD. There were no differences in the rate of antimanic response (YMRS change =30% or CGI-Improvement =2: 65% vs. 69%; P= 0.7) in the presence of comorbid ASD. Conclusion: No difference observed in the rate of antimanic response or tolerability to SGA monotherapy in the presence of ASD comorbidity.
引用
收藏
页码：28 / 33
页数：6
相关论文
共 50 条
  • [31] Comorbid Autism Spectrum Disorder and Antisocial Personality Disorder in Forensic Settings
    Carthy, Elliott
    Murphy, David
    JOURNAL OF THE AMERICAN ACADEMY OF PSYCHIATRY AND THE LAW, 2021, 49 (04): : 462 - 469
  • [32] Possible Overestimation of Comorbid Oppositional Defiant Disorder in Autism Spectrum Disorder
    Posar, Annio
    Visconti, Paola
    TURKISH ARCHIVES OF PEDIATRICS, 2024, 59 (03):
  • [33] Rates of Comorbid Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder
    McNally, Anna
    Weikum, Whitney
    Oberlander, Tim
    Lanphear, Nancy
    JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 2018, 39 (02): : S16 - S16
  • [34] Increased clinical and neurocognitive impairment in children with autism spectrum disorders and comorbid bipolar disorder
    Weissman, Adam S.
    Bates, Marsha E.
    RESEARCH IN AUTISM SPECTRUM DISORDERS, 2010, 4 (04) : 670 - 680
  • [35] The influence of comorbid disorders on the episodicity of bipolar disorder in youth
    Yen, S.
    Stout, R.
    Hower, H.
    Killam, M. A.
    Weinstock, L. M.
    Topor, D. R.
    Dickstein, D. P.
    Hunt, J. I.
    Gill, M. K.
    Goldstein, T. R.
    Goldstein, B. I.
    Ryan, N. D.
    Strober, M.
    Sala, R.
    Axelson, D. A.
    Birmaher, B.
    Keller, M. B.
    ACTA PSYCHIATRICA SCANDINAVICA, 2016, 133 (04) : 324 - 334
  • [36] Comorbidity of bipolar disorder and autism spectrum disorder - review paper
    Dunalska, Anna
    Rzeszutek, Marcin
    Debowska, Zuzanna
    Brynska, Anita
    PSYCHIATRIA POLSKA, 2021, 55 (06) : 1421 - 1431
  • [37] Overlap between Autism Spectrum Disorder and Bipolar Affective Disorder
    Skokauskas, Norbert
    Frodl, Thomas
    PSYCHOPATHOLOGY, 2015, 48 (04) : 209 - 216
  • [38] CHILDREN WITH AUTISM SPECTRUM DISORDER AND COMORBID SPECIFIC LEARNING DISORDER DEMONSTRATE COGNITIVE WEAKNESS COMPARED TO AUTISM SPECTRUM DISORDER ALONE
    McGuinness, Patrick S.
    Cook, Nathan E.
    Bush, Hillary
    Lind, Hannah
    Vuijk, Pieter J.
    Doyle, Alysa E.
    Braaten, Ellen B.
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2017, 56 (10): : S231 - S231
  • [39] EXAMINING THE COMORBIDITY OF BIPOLAR DISORDER AND AUTISM SPECTRUM DISORDERS: A LARGE CONTROLLED ANALYSIS OF PHENOTYPIC AND FAMILIAL CORRELATES IN YOUTH WITH BIPOLAR DISORDER
    Joshi, G.
    Biederman, J.
    Petty, C.
    Goldin, R. L.
    Wozniak, J.
    EUROPEAN PSYCHIATRY, 2012, 27
  • [40] Use and effectiveness of atypical antipsychotics in Autism Spectrum Disorder
    Ortega-Pineda, Lizbeth Aida
    Fernandez-Canedo, Lauro
    Toledo-Cardenas, Maria Rebeca
    Lopez-Meraz, Maria Leonor
    Garcia, Luis Isauro
    Coria-Avila, Genaro Alfonso
    Manzo-Denes, Jorge
    ENEUROBIOLOGIA, 2023, 14 (35):
12345