Response to Second Generation Antipsychotics in Youth with Comorbid Bipolar Disorder and Autism Spectrum Disorder

被引:24
|
作者
Joshi, Gagan [1 ,2 ]
Biederman, Joseph [2 ]
Wozniak, Janet [2 ]
Doyle, Robert [2 ]
Hammerness, Paul [2 ]
Galdo, Maribel
Sullivan, Nora
Williams, Courtney
Brethel, Kristin
Woodworth, K. Yvonne
Mick, Eric [2 ]
机构
[1] Massachusetts Gen Hosp, Pediat Psychopharmacol Res Program, Pediat Psychopharmacol Res Dept, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
Autism spectrum disorder (ASD); bipolar disorder (BPD); comorbid; DOUBLE-BLIND; RATING-SCALE; OPEN-LABEL; INFANTILE-AUTISM; CHILDREN; RISPERIDONE; PLACEBO; MANIA; ADOLESCENTS; ARIPIPRAZOLE;
D O I
10.1111/j.1755-5949.2010.00219.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: To assess the impact of comorbid autism spectrum disorders (ASD) on the response to second-generation antipsychotics (SGA) in pediatric bipolar disorder (BPD). Methods: Secondary analysis of identically designed 8-week open-label trials of SGA monotherapy (risperidone, olanzapine, quetiapine, ziprasidone, or aripiprazole) in youth with BPD. Results: Of the 151 BPD subjects 15% (n= 23) met criteria for comorbid ASD. There were no differences in the rate of antimanic response (YMRS change =30% or CGI-Improvement =2: 65% vs. 69%; P= 0.7) in the presence of comorbid ASD. Conclusion: No difference observed in the rate of antimanic response or tolerability to SGA monotherapy in the presence of ASD comorbidity.
引用
收藏
页码:28 / 33
页数:6
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