Response to Second Generation Antipsychotics in Youth with Comorbid Bipolar Disorder and Autism Spectrum Disorder

被引：24

作者：

Joshi, Gagan ^{[1
,2
]}

Biederman, Joseph ^{[2
]}

Wozniak, Janet ^{[2
]}

Doyle, Robert ^{[2
]}

Hammerness, Paul ^{[2
]}

Galdo, Maribel

Sullivan, Nora

Williams, Courtney

Brethel, Kristin

Woodworth, K. Yvonne

Mick, Eric ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Pediat Psychopharmacol Res Program, Pediat Psychopharmacol Res Dept, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2012年 / 18卷 / 01期

关键词：

Autism spectrum disorder (ASD); bipolar disorder (BPD); comorbid; DOUBLE-BLIND; RATING-SCALE; OPEN-LABEL; INFANTILE-AUTISM; CHILDREN; RISPERIDONE; PLACEBO; MANIA; ADOLESCENTS; ARIPIPRAZOLE;

D O I：

10.1111/j.1755-5949.2010.00219.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To assess the impact of comorbid autism spectrum disorders (ASD) on the response to second-generation antipsychotics (SGA) in pediatric bipolar disorder (BPD). Methods: Secondary analysis of identically designed 8-week open-label trials of SGA monotherapy (risperidone, olanzapine, quetiapine, ziprasidone, or aripiprazole) in youth with BPD. Results: Of the 151 BPD subjects 15% (n= 23) met criteria for comorbid ASD. There were no differences in the rate of antimanic response (YMRS change =30% or CGI-Improvement =2: 65% vs. 69%; P= 0.7) in the presence of comorbid ASD. Conclusion: No difference observed in the rate of antimanic response or tolerability to SGA monotherapy in the presence of ASD comorbidity.

引用

页码：28 / 33

页数：6

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