Serotonergic mechanisms influence the response to glucocorticoid treatment in TMJ arthritis

被引：15

作者：

Fredriksson, L ^{[1
]}

Alstergren, P ^{[1
]}

Kopp, S ^{[1
]}

机构：

[1] Karolinska Inst, Inst Odontol, Dept Clin Oral Physiol, S-14104 Huddinge, Sweden

来源：

MEDIATORS OF INFLAMMATION | 2005年 / 04期

关键词：

D O I：

10.1155/MI.2005.194

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.

引用

页码：194 / 201

页数：8

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