Ezetimibe/simvastatin (INEGY™) in the treatment of hyperlipidaemia

被引：16

作者：

Kastelein, JJP ^{[1
]}

Sankatsing, RR ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2005年 / 59卷 / 12期

关键词：

ezetimibe; simvastatin; INEGY (TM); low-density lipoprotein cholesterol; lipids;

D O I：

10.1111/j.1368-5031.2005.00737.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ezetimibe/simvastatin (INEGY(TM)), a dual inhibitor of both cholesterol production and absorption, is a new approach to the management of hyperlipidaemia. Recent studies have shown that it produces greater reductions in low-density lipoprotein (LDL) cholesterol than the single inhibition of statin therapy, enabling many more patients to achieve their LDL cholesterol treatment goals. With ezetimibe/simvastatin therapy, reductions of up to 61% from baseline have been seen in LDL cholesterol, with clear improvements in other associated lipid fractions. It has been well tolerated across all studies, with a safety profile similar to that of statin therapy. This article will review clinical experience to date with ezetimibe/simvastatin, commenting upon its place and potential value in the prevention of cardiovascular disease.

引用

页码：1464 / 1471

页数：8

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