Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

被引：47

作者：

Oh, Gabriel ^{[1
]}

Ebrahimi, Sasha ^{[1
]}

Carlucci, Matthew ^{[1
]}

Zhang, Aiping ^{[1
]}

Nair, Akhil ^{[1
]}

Groot, Daniel E. ^{[1
]}

Labrie, Viviane ^{[1
,2
]}

Jia, Peixin ^{[1
]}

Oh, Edward S. ^{[1
]}

Jeremian, Richie H. ^{[1
]}

Susic, Miki ^{[1
]}

Shrestha, Tenjin C. ^{[3
,4
]}

Ralph, Martin R. ^{[4
]}

Gordevicius, Juozas ^{[5
,6
]}

Koncevicius, Karolis ^{[5
,6
]}

Petronis, Art ^{[1
,5
]}

机构：

[1] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Krembil Family Epigenet Lab, Toronto, ON M5T 1R8, Canada

[2] Van Andel Res Inst, Ctr Neurodegenerat Sci, Grand Rapids, MI 49503 USA

[3] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada

[4] Univ Toronto, Dept Psychol, Toronto, ON M5S 3G5, Canada

[5] Vilnius Univ, Life Sci Ctr, Inst Biotechnol, Vilnius, Lithuania

[6] Vilnius Univ, Inst Data Sci & Digital Technol, LT-08663 Vilnius, Lithuania

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

DNA METHYLATION; GENE-EXPRESSION; C-MYC; DISEASE; CLOCK; MAMMALS; PROTEIN; 5-HYDROXYMETHYLCYTOSINE; 5-METHYLCYTOSINE; TRANSCRIPTION;

D O I：

10.1038/s41467-018-03073-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration.

引用

页数：11

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