Connecting Threads: Epigenetics and Metabolism

被引：248

作者：

Katada, Sayako ^{[1
]}

Imhof, Axel ^{[1
,2
]}

Sassone-Corsi, Paolo ^{[1
]}

机构：

[1] Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92697 USA

[2] Univ Munich, Adolf Butenandt Inst, Munich Ctr Integrated Prot Sci, D-80336 Munich, Germany

来源：

CELL | 2012年 / 148卷 / 1-2期

关键词：

HISTONE ACETYLATION; CIRCADIAN CONTROL; PHOSPHORYLATION; COMPLEXES; GROWTH; GENE;

D O I：

10.1016/j.cell.2012.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that histones act as metabolic sensors, converting changes in metabolism into stable patterns of gene expression. The challenge will now be to understand how localized fluctuations in levels of metabolites control chromatin modifiers in space and time, translating a dynamic metabolic state into a histone map.

引用

页码：24 / 28

页数：5

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